Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2000-11-9
pubmed:databankReference
pubmed:abstractText
Neurogranin/RC3 is a neural-specific Ca(2+)-sensitive calmodulin (CaM)-binding protein whose CaM-binding affinity is modulated by phosphorylation and oxidation. Here we show that deletion of the Ng gene in mice did not result in obvious developmental or neuroanatomical abnormalities but caused an impairment of spatial learning and changes in hippocampal short- and long-term plasticity (paired-pulse depression, synaptic fatigue, long-term potentiation induction). These deficits were accompanied by a decreased basal level of the activated Ca(2+)/CaM-dependent kinase II (CaMKII) ( approximately 60% of wild type). Furthermore, hippocampal slices of the mutant mice displayed a reduced ability to generate activated CaMKII after stimulation of protein phosphorylation and oxidation by treatments with okadaic acid and sodium nitroprusside, respectively. These results indicate a central role of Ng in the regulation of CaMKII activity with decisive influences on synaptic plasticity and spatial learning.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-10075657, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-10077673, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-10088994, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-10402188, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-1378648, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-1548487, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-1824695, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-2231781, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-2462028, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-2648947, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-4296699, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-7381775, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-7530878, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-7620629, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-7675078, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-7730337, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-7775448, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-7778873, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-8080473, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-8145143, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-8293295, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-8798403, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-9106358, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-9197267, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-9208866, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-9396008, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-9452388, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-9620694, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-9651538, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-9690475, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-9880498, http://linkedlifedata.com/resource/pubmed/commentcorrection/11016969-9890937
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11232-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:11016969-Animals, pubmed-meshheading:11016969-Base Sequence, pubmed-meshheading:11016969-Calcium-Calmodulin-Dependent Protein Kinase Type 2, pubmed-meshheading:11016969-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:11016969-Calmodulin-Binding Proteins, pubmed-meshheading:11016969-DNA Primers, pubmed-meshheading:11016969-Female, pubmed-meshheading:11016969-Learning, pubmed-meshheading:11016969-Male, pubmed-meshheading:11016969-Mice, pubmed-meshheading:11016969-Mice, Inbred C57BL, pubmed-meshheading:11016969-Mice, Knockout, pubmed-meshheading:11016969-Molecular Sequence Data, pubmed-meshheading:11016969-Nerve Tissue Proteins, pubmed-meshheading:11016969-Neurogranin, pubmed-meshheading:11016969-Neuronal Plasticity, pubmed-meshheading:11016969-Signal Transduction
pubmed:year
2000
pubmed:articleTitle
Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice.
pubmed:affiliation
Endocrinology and Reproduction Research Branch and Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
pubmed:publicationType
Journal Article, In Vitro