Linked Life Data

11016826

Source:http://linkedlifedata.com/resource/pubmed/id/11016826

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-1-4
pubmed:abstractText
Ouabain, that has been isolated from bovine adrenals and hypothalamus, is a new cardiotonic steroid hormone, which is either synthesized in the adrenals or stored there after it has absorbed from the diet. Little is known in vivo which events may lead to the release of ouabain into blood. Moreover, a binding protein for cardiotonic steroids exists in blood, which binds cardiac glycosides with high affinity. It may affect the action of endogenous ouabain on heart and circulation, but the physiological function of this protein is unclear. To realize, which physiological stimuli in vivo may affect blood concentrations of endogenous ouabain and which function the cardiotonic binding protein may have in modulating ouabain effects, the effect of physical exercise on endogenous ouabain was studied and the tissue distribution of its binding protein was investigated. We found that endogenous ouabain changes rapidly in blood upon physical exercise and behaves like expected for a hormone of circulation. The cardiotonic steroid binding globulin shows the highest concentration in the kidney, which suggests that sodium pumps of the kidney are protected against its inhibition by ouabain which would lead not only to natriuresis but also to a deleterious loss of glucose, amino acids and phosphate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0916-9636
pubmed:author
pubmed:issnType
Print
pubmed:volume
23 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S93-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Endogenous ouabain and its binding globulin: effects of physical exercise and study on the globulin's tissue distribution.
pubmed:affiliation
Institute of Biochemistry and Endocrinology, Faculty of Veterinary Medicine, Justus-Liebig-University Giessen, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't