Source:http://linkedlifedata.com/resource/pubmed/id/11016711
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2000-10-3
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| pubmed:abstractText |
The accuracy of the sentinel node technique in the evaluation of axillary node involvement in breast cancer was evaluated in 83 consecutive patients with monofocal T1-2 carcinoma, who were clinically N0 and who underwent lymphoscintigraphy with 99mTc-colloid integrated with intraoperative sentinel node detection by a portable probe. Lymphoscintigraphy revealed at least one sentinel node in 75 patients (90.4%), always identified by the probe. In eight patients (9.6%) the sentinel node was detected neither by lymphoscintigraphy nor by the probe. All removed lymph nodes were analyzed by hematoxylin-eosin histology and the sentinel node by immunostaining. In 28/75 patients (37.3%) at least one metastatic axillary lymph node was detected; in 16 of the 28 N+ subjects (57%) only the sentinel node was positive. The false negative rate (sentinel node negative/other axillary lymph nodes positive) was 17.85% (5/28 patients). In 9/23 patients (39%) micrometastases were found in the sentinel node only. In conclusion, specific sentinel node positivity in 57% of cases supports the validity of the sentinel node concept. Moreover, nine patients would have been considered N0 by standard hematoxylin-eosin histology without sentinel node-aided immunostaining. A 17.8% false negative rate calls for caution in patients with negative sentinel nodes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
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| pubmed:issn |
0300-8916
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
86
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
309-11
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| pubmed:dateRevised |
2008-12-12
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| pubmed:meshHeading |
pubmed-meshheading:11016711-Adult,
pubmed-meshheading:11016711-Aged,
pubmed-meshheading:11016711-Axilla,
pubmed-meshheading:11016711-Breast Neoplasms,
pubmed-meshheading:11016711-False Negative Reactions,
pubmed-meshheading:11016711-Female,
pubmed-meshheading:11016711-Hospitals, Community,
pubmed-meshheading:11016711-Humans,
pubmed-meshheading:11016711-Italy,
pubmed-meshheading:11016711-Lymph Nodes,
pubmed-meshheading:11016711-Lymphatic Metastasis,
pubmed-meshheading:11016711-Middle Aged,
pubmed-meshheading:11016711-Neoplasm Staging,
pubmed-meshheading:11016711-Sentinel Lymph Node Biopsy
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| pubmed:articleTitle |
Sentinel node biopsy in breast cancer: the experience of Brescia Civic Hospital.
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| pubmed:affiliation |
Divisione di Medicina Nucleare, Spedali Civili, Brescia, Italy.
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| pubmed:publicationType |
Journal Article
|