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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-10-16
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pubmed:abstractText |
Feline leukaemia virus (FeLV) nucleic acid vaccination of domestic cats affords protection against viraemia and the development of latency without inducing antiviral antibodies.1 To determine the contribution of cell-mediated immunity to the control of virus replication and clearance from the host, FeLV-specific cytotoxic T lymphocyte (CTL) responses were compared in vaccine-protected, transiently viraemic, and persistently viraemic cats. Vaccinal immunity was associated with the detection of higher levels of virus-specific effector CTL in the peripheral blood and lymphoid organs to FeLV Gag/Pro and Env antigens than those observed in unvaccinated control, persistently viraemic cats (P<0.001). Likewise, higher levels of virus-specific CTLs were also observed in transiently viraemic cats which recovered following exposure to FeLV. In cats that controlled their infection, recognition of Gag/Pro antigens was significantly higher than the recognition of Env antigens. This is the first report highlighting the very significant role that virus-specific CTL have in determining the outcome of FeLV infection in either vaccinated cats or cats recovering naturally from FeLV exposure.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-10229227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-10482595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-1323704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-1662057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-1666090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-1666095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-199981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-2083233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-2993416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-7543872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-7585062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-7637030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-7752758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-8057464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-8057491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-8207839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-8554908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-8596933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-8709246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-8825325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-8871667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-8892875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-9188572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-9206992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-9266988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-9516110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-9696827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11012762-9883837
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
120-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11012762-Animals,
pubmed-meshheading:11012762-Antibodies, Viral,
pubmed-meshheading:11012762-Cats,
pubmed-meshheading:11012762-Cytotoxicity, Immunologic,
pubmed-meshheading:11012762-Immunity, Cellular,
pubmed-meshheading:11012762-Leukemia Virus, Feline,
pubmed-meshheading:11012762-Retroviridae Infections,
pubmed-meshheading:11012762-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11012762-Tumor Virus Infections,
pubmed-meshheading:11012762-Vaccination,
pubmed-meshheading:11012762-Vaccines, DNA,
pubmed-meshheading:11012762-Viral Vaccines,
pubmed-meshheading:11012762-Viremia
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pubmed:year |
2000
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pubmed:articleTitle |
Feline leukaemia virus: protective immunity is mediated by virus-specific cytotoxic T lymphocytes.
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pubmed:affiliation |
Retrovirus Research Laboratory, Department of Veterinary Pathology, University of Glasgow, Glasgow, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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