To determine the population pharmacokinetic (PK) parameters of doxorubicin (Dox), etoposide (Eto) and ifosfamide (Ifo) in small cell lung cancer (SCLC) patients, to assess the potential relationship between those parameters and to estimate the impact of individual morphological and biological covariates on patients' PK parameters.
Medical Oncology Unit and EA 643, Centre Hospitalier Lyon-Sud, Pierre-Bénite, Pharmacology Unit, Centre Léon Bérard, Lyon, France. Gilles.Freyer@chu-lyon.fr