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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2001-1-3
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pubmed:abstractText |
trans-4-Aminomethylcyclohexanecarbonyl-Tyr(O-Pic)-octylamide (YO-2) inhibited plasmin (PL) selectively, while trans-4-aminomethylcyclohexanecarbonyl-Phe-4-carboxymethylanili de (YO-1) inhibited plasma kallikrein (PK). YO-2 induced apoptosis of M1 (melanoma) cell line and HT29 colon carcinoma cells during 24 h through activation of caspase-3, while YO-1 did not affect either cell line even during 48 h.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2217-21
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11012033-Antineoplastic Agents,
pubmed-meshheading:11012033-Apoptosis,
pubmed-meshheading:11012033-Caspase 3,
pubmed-meshheading:11012033-Caspases,
pubmed-meshheading:11012033-Dipeptides,
pubmed-meshheading:11012033-Fibrinolysin,
pubmed-meshheading:11012033-HT29 Cells,
pubmed-meshheading:11012033-Humans,
pubmed-meshheading:11012033-Molecular Structure,
pubmed-meshheading:11012033-Plasma Kallikrein,
pubmed-meshheading:11012033-Structure-Activity Relationship,
pubmed-meshheading:11012033-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and HT29 cell lines.
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pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan. okada@pharm.kobegakuin.ac.jp
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pubmed:publicationType |
Journal Article
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