Source:http://linkedlifedata.com/resource/pubmed/id/11012024
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
|
| pubmed:dateCreated |
2001-1-3
|
| pubmed:abstractText |
Beta-lactam antibiotics such as the cephalosporins and penicillins have diminished clinical effectiveness due to the hydrolytic activity of diverse beta-lactamases, especially those in molecular classes A and C. A structure activity relationship (SAR) study of a high-throughput screening lead resulted in the discovery of a potent and selective non-beta-lactam inhibitor of class C beta-lactamases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2179-82
|
| pubmed:meshHeading |
pubmed-meshheading:11012024-Drug Evaluation, Preclinical,
pubmed-meshheading:11012024-Enzyme Inhibitors,
pubmed-meshheading:11012024-Molecular Structure,
pubmed-meshheading:11012024-Piperacillin,
pubmed-meshheading:11012024-Rhodanine,
pubmed-meshheading:11012024-Structure-Activity Relationship,
pubmed-meshheading:11012024-beta-Lactamases
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors.
|
| pubmed:affiliation |
Antimicrohial Agents Research, The R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA. egrant@prius.jnj.com
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| pubmed:publicationType |
Journal Article
|