|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0014597,
umls-concept:C0022077,
umls-concept:C0030705,
umls-concept:C0031916,
umls-concept:C0031928,
umls-concept:C0040715,
umls-concept:C0271084,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C1522702
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2001-1-3
|
|
pubmed:abstractText |
This prospective, non-controlled pilot study investigates the practicability of IPE translocation and functional outcome in ARMD patients. Removal of submacular choroidal neovascularization (CNV) in age-related macular degeneration (ARMD) is usually associated with RPE damage and poor visual prognosis. Homologous RPE transplants fail to preserve macular function, possibly due to immune rejection. Instead of homologous RPE, we suggest translocating autologous iris pigment epithelium (IPE), building on earlier evidence from animal and in vitro investigations that IPE can substitute RPE functions in the experimental animal. Immunological cell rejection is avoided.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0721-832X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
238
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
631-41
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11011682-Aged,
pubmed-meshheading:11011682-Aged, 80 and over,
pubmed-meshheading:11011682-Cell Transplantation,
pubmed-meshheading:11011682-Choroidal Neovascularization,
pubmed-meshheading:11011682-Exudates and Transudates,
pubmed-meshheading:11011682-Female,
pubmed-meshheading:11011682-Fluorescein Angiography,
pubmed-meshheading:11011682-Fundus Oculi,
pubmed-meshheading:11011682-Humans,
pubmed-meshheading:11011682-Iris,
pubmed-meshheading:11011682-Macula Lutea,
pubmed-meshheading:11011682-Macular Degeneration,
pubmed-meshheading:11011682-Middle Aged,
pubmed-meshheading:11011682-Pigment Epithelium of Eye,
pubmed-meshheading:11011682-Pilot Projects,
pubmed-meshheading:11011682-Prognosis,
pubmed-meshheading:11011682-Prospective Studies,
pubmed-meshheading:11011682-Recurrence,
pubmed-meshheading:11011682-Transplantation, Autologous,
pubmed-meshheading:11011682-Visual Acuity,
pubmed-meshheading:11011682-Vitrectomy
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Iris pigment epithelial cell translocation in exudative age-related macular degeneration. A pilot study in patients.
|
|
pubmed:affiliation |
Augenklinik, Universitätsklinikum der RWTH Aachen, Germany. alappas@post.klinikum.rwth-aachen.de
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study
|
