Source:http://linkedlifedata.com/resource/pubmed/id/11011034
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2000-11-28
|
| pubmed:abstractText |
We have evaluated the effects of either intravenous or intraplantar administration of racemic-, S(+)- and R(-)-flurbiprofen on the spinal c-Fos protein expression after a single noxious heat stimulation (52 degrees C for 15 s) of the rat hindpaw in urethane anaesthetized rats. Two hours after noxious heat, numerous c-Fos protein immunoreactive (c-Fos-IR) nuclei (>70 c-Fos-IR nuclei per section at the level of L4-L5 segments) were observed with essential localization in the superficial (I-II) laminae of the spinal dorsal horn, i.e. areas containing numerous neurons driven exclusively by noxious stimuli. Considering the number of c-Fos-IR nuclei in laminae I-II, the intravenous injection of racemic-flurbiprofen (0.3, 3 and 9 mg/kg) was inefficacious and S(+)-flurbiprofen had weak and non-dose-related effects. The same doses of R(-)-flurbiprofen produced dose-related effects (r=0.58, P<0.05) with weak, but significant, effects for doses of 3 and 9 mg/kg (18+/-6% and 26+/-5% reduction of the number of noxious heat-evoked c-Fos-IR nuclei in laminae I-II, P<0.05 and P<0.01, respectively). The weak effects of R(-)-flurbiprofen are probably due to the central site of action since the intraplantar injection of a relatively high dose of 30 microg is inefficacious. These results provide further evidence for weak effects of non-steroidal anti-inflammatory drugs and their enantiomers on the acute responses to nociceptive stimulus which are very efficacious upon inflammatory nociception, but not upon brief noxious heat-evoked nociception.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
406
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
59-67
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:11011034-Anesthesia,
pubmed-meshheading:11011034-Animals,
pubmed-meshheading:11011034-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11011034-Dose-Response Relationship, Drug,
pubmed-meshheading:11011034-Flurbiprofen,
pubmed-meshheading:11011034-Hindlimb,
pubmed-meshheading:11011034-Hot Temperature,
pubmed-meshheading:11011034-Immunohistochemistry,
pubmed-meshheading:11011034-Injections,
pubmed-meshheading:11011034-Injections, Intravenous,
pubmed-meshheading:11011034-Lumbar Vertebrae,
pubmed-meshheading:11011034-Male,
pubmed-meshheading:11011034-Nociceptors,
pubmed-meshheading:11011034-Pain Measurement,
pubmed-meshheading:11011034-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:11011034-Rats,
pubmed-meshheading:11011034-Rats, Sprague-Dawley,
pubmed-meshheading:11011034-Spinal Cord,
pubmed-meshheading:11011034-Stereoisomerism
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Effects of flurbiprofen and its enantiomers on the spinal c-Fos protein expression induced by noxious heat stimuli in the anaesthetized rat.
|
| pubmed:affiliation |
Unité de Recherches de Physiopharmacologie du Système Nerveux, INSERM U161, 2 rue d'Alésia, F-75014 and EPHE, Paris, France. buritova@broca.inserm.fr
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|