Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2000-10-17
pubmed:databankReference
pubmed:abstractText
Among several bacterial species belonging to the general Gordonia, Mycobacterium, Micromonospora, Pseudomonas, and Rhodococcus, only two mycobacterial isolates, Mycobacterium fortuitum strain NF4 and the new isolate Mycobacterium ratisbonense strain SD4, which was isolated from a sewage treatment plant, were capable of utilizing the multiply branched hydrocarbon squalane (2,6,10,15,19, 23-hexamethyltetracosane) and its analogous unsaturated hydrocarbon squalene as the sole carbon source for growth. Detailed degradation studies and high-pressure liquid chromatography analysis showed a clear decrease of the concentrations of squalane and squalene during biomass increase. These results were supported by resting-cell experiments using strain SD4 and squalane or squalene as the substrate. The degradation of acyclic isoprenoids and alkanes as well as of acids derived from these compounds was also investigated. Inhibition of squalane and squalene degradation by acrylic acid indicated the possible involvement of beta-oxidation in the degradation route. To our knowledge, this is the first report demonstrating the biodegradation of squalane by using defined axenic cultures.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-10555361, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-10612748, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-10742254, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-1115507, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-13747777, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-14445211, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-4004225, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-4416282, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-500568, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-539824, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-681275, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-8863440, http://linkedlifedata.com/resource/pubmed/commentcorrection/11010899-942051
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0099-2240
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4462-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Microbial degradation of the multiply branched alkane 2,6,10,15,19, 23-hexamethyltetracosane (Squalane) by Mycobacterium fortuitum and Mycobacterium ratisbonense.
pubmed:affiliation
Institut für Mikrobiologie, Westfälische Wilhelms-Universität Münster, D-48149 Münster, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't