| pubmed-article:11009098 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11009098 | lifeskim:mentions | umls-concept:C1335877 | lld:lifeskim |
| pubmed-article:11009098 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:11009098 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:11009098 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:11009098 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11009098 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:11009098 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11009098 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11009098 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11009098 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11009098 | pubmed:dateCreated | 2000-10-12 | lld:pubmed |
| pubmed-article:11009098 | pubmed:abstractText | TGF-beta plays an important role in immune regulation in vivo and affects T cell differentiation in vitro. Here we describe how TGF-beta modulates Th2 development in vitro and investigate its mechanisms of action. TGF-beta down-regulated Th2 development of naive CD4+ Mel-14high T cells derived from the DO11.10 ovalbumin-specific TCR-transgenic mouse, and this was observed both in cultures driven with anti-CD3 and anti-CD28 and with splenic APC and antigen. TGF-beta down-regulated GATA-3 expression in developing Th2 and these cells showed a diminished IL-4-induced STAT6 activation. We found, however, that naive cells driven in Th2 conditions with TGF-beta did not show a significantly decreased STAT6 activation, suggesting that TGF-beta inhibits Th2 development via a STAT6-independent mechanism. | lld:pubmed |
| pubmed-article:11009098 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11009098 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11009098 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11009098 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11009098 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:11009098 | pubmed:author | pubmed-author:CraigDD | lld:pubmed |
| pubmed-article:11009098 | pubmed:author | pubmed-author:O'GarraAA | lld:pubmed |
| pubmed-article:11009098 | pubmed:author | pubmed-author:MurphyE EEE | lld:pubmed |
| pubmed-article:11009098 | pubmed:author | pubmed-author:TomlinsonM... | lld:pubmed |
| pubmed-article:11009098 | pubmed:author | pubmed-author:HeathV LVL | lld:pubmed |
| pubmed-article:11009098 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11009098 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:11009098 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11009098 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11009098 | pubmed:pagination | 2639-49 | lld:pubmed |
| pubmed-article:11009098 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:meshHeading | pubmed-meshheading:11009098... | lld:pubmed |
| pubmed-article:11009098 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11009098 | pubmed:articleTitle | TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression. | lld:pubmed |
| pubmed-article:11009098 | pubmed:affiliation | Department of Immunology, DNAX Research Institute, Palo Alto, USA. | lld:pubmed |
| pubmed-article:11009098 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11009098 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11009098 | lld:pubmed |
