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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2000-10-12
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pubmed:abstractText |
TGF-beta plays an important role in immune regulation in vivo and affects T cell differentiation in vitro. Here we describe how TGF-beta modulates Th2 development in vitro and investigate its mechanisms of action. TGF-beta down-regulated Th2 development of naive CD4+ Mel-14high T cells derived from the DO11.10 ovalbumin-specific TCR-transgenic mouse, and this was observed both in cultures driven with anti-CD3 and anti-CD28 and with splenic APC and antigen. TGF-beta down-regulated GATA-3 expression in developing Th2 and these cells showed a diminished IL-4-induced STAT6 activation. We found, however, that naive cells driven in Th2 conditions with TGF-beta did not show a significantly decreased STAT6 activation, suggesting that TGF-beta inhibits Th2 development via a STAT6-independent mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GATA3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Gata3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Maf protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-maf,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2639-49
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11009098-Animals,
pubmed-meshheading:11009098-DNA-Binding Proteins,
pubmed-meshheading:11009098-Down-Regulation,
pubmed-meshheading:11009098-GATA3 Transcription Factor,
pubmed-meshheading:11009098-Interferon-gamma,
pubmed-meshheading:11009098-Interleukin-4,
pubmed-meshheading:11009098-Mice,
pubmed-meshheading:11009098-Mice, Inbred BALB C,
pubmed-meshheading:11009098-Phosphorylation,
pubmed-meshheading:11009098-Proto-Oncogene Proteins,
pubmed-meshheading:11009098-Proto-Oncogene Proteins c-maf,
pubmed-meshheading:11009098-STAT6 Transcription Factor,
pubmed-meshheading:11009098-Th1 Cells,
pubmed-meshheading:11009098-Th2 Cells,
pubmed-meshheading:11009098-Trans-Activators,
pubmed-meshheading:11009098-Transforming Growth Factor beta
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pubmed:year |
2000
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pubmed:articleTitle |
TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression.
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pubmed:affiliation |
Department of Immunology, DNAX Research Institute, Palo Alto, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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