Source:http://linkedlifedata.com/resource/pubmed/id/11007920
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2000-10-13
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| pubmed:abstractText |
GW395058, a PEGylated peptide agonist of the thrombopoietin receptor, stimulates megakaryocytopoiesis and has previously been shown to increase platelet counts in vivo. The pharmacokinetics and pharmacodynamics of GW395058 were characterized using a randomized, crossover study in a large-animal model (dog) of chemotherapy-induced thrombocytopenia. Nine beagle dogs received i.v. carboplatin (350 mg/m(2)) on day 0 and day 28. GW395058 (1.31 mg/kg) (n = 6) or vehicle control (n = 3) was administered on day 1 and day 29 either as an i.v. bolus or s.c. injection. After i.v. administration, peak concentrations of GW395058 occurred rapidly, while the half-life averaged approximately 56 h. Bioavailability (+/- standard deviation) of GW395058 given s.c. was 78.2% (20.9%). GW395058 (i.v. and s.c.) ameliorated the platelet nadir (p = 0.0086) and resulted in a shorter time to recovery compared to the control group. The mean nadir platelet counts following carboplatin administration were 197,000 cells/microl (80,000) for the i.v. GW395058-dose group, 183,000 cells/microl (72,000) for the s.c.-dose group and 71,000 cells/microl (38,000) for the vehicle-alone group. GW395058 reduced the thrombocytopenic effects of carboplatin in dogs. No GW395058-related adverse side effects were observed.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carboplatin,
http://linkedlifedata.com/resource/pubmed/chemical/GW395058,
http://linkedlifedata.com/resource/pubmed/chemical/MPL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thrombopoietin,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombopoietin
|
| pubmed:status |
MEDLINE
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| pubmed:issn |
1066-5099
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
360-5
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11007920-Animals,
pubmed-meshheading:11007920-Carboplatin,
pubmed-meshheading:11007920-Dogs,
pubmed-meshheading:11007920-Female,
pubmed-meshheading:11007920-Injections, Intravenous,
pubmed-meshheading:11007920-Injections, Subcutaneous,
pubmed-meshheading:11007920-Leukocyte Count,
pubmed-meshheading:11007920-Male,
pubmed-meshheading:11007920-Metabolic Clearance Rate,
pubmed-meshheading:11007920-Molecular Mimicry,
pubmed-meshheading:11007920-Neoplasm Proteins,
pubmed-meshheading:11007920-Neutrophils,
pubmed-meshheading:11007920-Peptides,
pubmed-meshheading:11007920-Platelet Count,
pubmed-meshheading:11007920-Proto-Oncogene Proteins,
pubmed-meshheading:11007920-Receptors, Cytokine,
pubmed-meshheading:11007920-Receptors, Thrombopoietin,
pubmed-meshheading:11007920-Thrombocytopenia,
pubmed-meshheading:11007920-Thrombopoietin
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| pubmed:year |
2000
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| pubmed:articleTitle |
The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia.
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| pubmed:affiliation |
North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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