Linked Life Data

11007311

Source:http://linkedlifedata.com/resource/pubmed/id/11007311

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-1-2
pubmed:abstractText
Supporting cells of Corti's organ are electrically coupled via gap junctions. They probably serve to maintain the unique cochlear environment that is required for normal sensory function. In this study we used input capacitance measurements under whole-cell voltage-clamp conditions to evaluate the effects of nitric oxide on gap junctional communication between pairs of isolated supporting Deiters cells. We show that the nitric oxide (NO) donor sodium nitroprusside causes the uncoupling of Deiters cells, and that an NO synthase inhibitor blocks the effect. The cGMP analogue 8-bromo-cGMP also uncouples Deiters cells. With either treatment, the input capacitance of pairs of Deiters cells drops to single-cell levels within minutes of application, indicative of electrical uncoupling. We surmise that the NO/cGMP pathway may serve to modulate normal cochlear homeostasis and possibly plays a role in ototoxic mechanisms.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
440
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
710-2
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ.
pubmed:affiliation
Section of Otolaryngology, Yale University School of Medicine, New Haven, CT 06510, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't