Source:http://linkedlifedata.com/resource/pubmed/id/11005735
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2001-8-16
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| pubmed:abstractText |
The association of xerostomia and salivary gland hypofunction with HIV infection has been established for men but not for women. We investigated the prevalence of these conditions in a national cohort (n = 733) of HIV-positive and at-risk HIV-negative women. Participants in this prospective cross-sectional study were recruited from the Women's Interagency HIV Study (WIHS) at five outpatient USA clinics. Xerostomia was assessed based on "yes" responses to a dry-mouth questionnaire. Samples of unstimulated whole and chewing-stimulated whole saliva were collected under standardized conditions. The major salivary glands were also evaluated clinically. The prevalence of dry-mouth complaint, the absence of saliva upon palpation, and zero unstimulated whole saliva (flow rate = 0 mL/min) were significantly (p = 0.001) higher in HIV-positive women. Adjusted odds of zero unstimulated whole saliva were significantly (p = 0.02) higher in HIV-positive women vs. HIV-negative women (OR = 2.86; 95% CI, 1.23 to 6.63). Significant (p = 0.03) univariate association was found between zero unstimulated whole saliva and CD4 counts. Adjusted odds of zero unstimulated whole saliva were significantly (p = 0.02) higher for HIV-positive women with CD4 < 200 compared with those with CD4 > 500 (OR = 2.61; 95% CI, 1.17 to 5.85). Chewing-stimulated flow rates were not significantly different between seropositive and seronegative women. The prevalence of xerostomia and salivary gland hypofunction appears to be significantly higher in HIV-positive women relative to a comparable group of at-risk seronegative women. Immunosuppression levels measured by CD4 cell counts are significantly associated with xerostomia and salivary gland hypofunction in a population of HIV-positive women.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
D
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0022-0345
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
79
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1502-7
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11005735-Adolescent,
pubmed-meshheading:11005735-Adult,
pubmed-meshheading:11005735-CD4 Lymphocyte Count,
pubmed-meshheading:11005735-Chi-Square Distribution,
pubmed-meshheading:11005735-Cohort Studies,
pubmed-meshheading:11005735-Female,
pubmed-meshheading:11005735-HIV Infections,
pubmed-meshheading:11005735-Humans,
pubmed-meshheading:11005735-Logistic Models,
pubmed-meshheading:11005735-Middle Aged,
pubmed-meshheading:11005735-Odds Ratio,
pubmed-meshheading:11005735-Parotid Gland,
pubmed-meshheading:11005735-Prospective Studies,
pubmed-meshheading:11005735-Saliva,
pubmed-meshheading:11005735-Salivary Glands,
pubmed-meshheading:11005735-Secretory Rate,
pubmed-meshheading:11005735-Statistics, Nonparametric,
pubmed-meshheading:11005735-Submandibular Gland,
pubmed-meshheading:11005735-Xerostomia
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
The prevalence of xerostomia and salivary gland hypofunction in a cohort of HIV-positive and at-risk women.
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| pubmed:affiliation |
University of Southern California, School of Dentistry, Department of Dental Medicine & Public Health, Los Angeles 90089-0641, USA. navazesh@hsc.usc.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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