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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2000-10-19
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pubmed:abstractText |
A new mouse cysteine protease, termed cathepsin R, has been identified. The complete nucleotide sequence of this gene was derived from a set of cDNAs generated from 15.5-day mouse placenta. Sequence analysis revealed an open reading frame encoding a 334 amino acid long polypeptide closely related to placentally expressed cathepsins P, Q, and M. RT-PCR analysis indicated that cathepsin R is only expressed in placenta and thus is a new member of the emerging family of cathepsins whose expression is regulated during mouse embryonic development. Modeling and structural analysis suggests that cathepsin R will have a restricted substrate specificity when compared to that of cathepsin L.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
1492
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
488-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11004518-Amino Acid Sequence,
pubmed-meshheading:11004518-Animals,
pubmed-meshheading:11004518-Base Sequence,
pubmed-meshheading:11004518-Cysteine Endopeptidases,
pubmed-meshheading:11004518-DNA, Complementary,
pubmed-meshheading:11004518-Mice,
pubmed-meshheading:11004518-Models, Molecular,
pubmed-meshheading:11004518-Molecular Sequence Data,
pubmed-meshheading:11004518-Placenta,
pubmed-meshheading:11004518-Polymerase Chain Reaction,
pubmed-meshheading:11004518-Protein Conformation,
pubmed-meshheading:11004518-Sequence Homology, Amino Acid,
pubmed-meshheading:11004518-Serine Endopeptidases,
pubmed-meshheading:11004518-Substrate Specificity
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pubmed:year |
2000
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pubmed:articleTitle |
Characterization of mouse cathepsin R, a new member of a family of placentally expressed cysteine proteases.
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pubmed:affiliation |
Laboratory of Clinical Biochemistry, Department of Research, Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA. ksolchur@nemours.org
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pubmed:publicationType |
Journal Article
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