| pubmed-article:11004133 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11004133 | lifeskim:mentions | umls-concept:C0348321 | lld:lifeskim |
| pubmed-article:11004133 | lifeskim:mentions | umls-concept:C0039082 | lld:lifeskim |
| pubmed-article:11004133 | pubmed:dateCreated | 2000-10-27 | lld:pubmed |
| pubmed-article:11004133 | pubmed:abstractText | It has been reported recently that Haemophilus influenzae can elicit an axonal form of Guillain-Barré syndrome. To investigate the incidence and features of H. influenzae-related Guillain-Barré syndrome, anti-H. influenzae antibody titres were measured by enzyme-linked immunosorbent assay (ELISA) in 46 consecutive Japanese patients with Guillain-Barré syndrome, 49 normal controls, 24 patients with multiple sclerosis and 27 patients with amyotrophic lateral sclerosis (ALS). Whole bacteria of non-encapsulated (non-typable) H. influenzae isolated from one of the Guillain-Barré syndrome patients was the antigen used. Elevated anti-H. influenzae antibodies for two or three classes of IgG, IgM and IgA were found in six (13%) Guillain-Barré syndrome patients, but not in the normal controls and patients with multiple sclerosis or ALS. The incidence was significantly higher in patients with Guillain-Barré syndrome than in the normal controls (P = 0.01) and patients with multiple sclerosis or ALS (P = 0.009). Western blot analysis confirmed that the H. influenzae-positive patients' IgG recognized the lipopolysaccharides of H. influenzae. Guillain-Barré syndrome patients with anti-H. influenzae antibodies showed relatively uniform clinical and laboratory features: prodromal respiratory infection, less frequent cranial and sensory nerve involvement, pure motor axonal degeneration on electrophysiology, and positivity for IgG anti-GM1 antibodies. Although the features were similar to those in Guillain-Barré syndrome patients infected by Campylobacter jejuni, the recoveries seemed to be better in patients with H. influenzae-related Guillain-Barré syndrome. It is concluded that a form of Guillain-Barré syndrome occurs after respiratory infection by H. influenzae in the Japanese population. A particular strain of non-typable H. influenzae has a ganglioside GM1-like structure and elicits axonal Guillain-Barré syndrome similar to C. jejuni-related Guillain-Barré syndrome. | lld:pubmed |
| pubmed-article:11004133 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11004133 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11004133 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11004133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11004133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11004133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11004133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11004133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11004133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11004133 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11004133 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11004133 | pubmed:issn | 0006-8950 | lld:pubmed |
| pubmed-article:11004133 | pubmed:author | pubmed-author:HattoriTT | lld:pubmed |
| pubmed-article:11004133 | pubmed:author | pubmed-author:MoriMM | lld:pubmed |
| pubmed-article:11004133 | pubmed:author | pubmed-author:KuwabaraSS | lld:pubmed |
| pubmed-article:11004133 | pubmed:author | pubmed-author:MiyakeMM | lld:pubmed |
| pubmed-article:11004133 | pubmed:author | pubmed-author:KurokiHH | lld:pubmed |
| pubmed-article:11004133 | pubmed:author | pubmed-author:NodaMM | lld:pubmed |
| pubmed-article:11004133 | pubmed:author | pubmed-author:KannoHH | lld:pubmed |
| pubmed-article:11004133 | pubmed:author | pubmed-author:OgawaraKK | lld:pubmed |
| pubmed-article:11004133 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11004133 | pubmed:volume | 123 ( Pt 10) | lld:pubmed |
| pubmed-article:11004133 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11004133 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11004133 | pubmed:pagination | 2171-8 | lld:pubmed |
| pubmed-article:11004133 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:11004133 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11004133 | pubmed:articleTitle | Haemophilus influenzae infection and Guillain-Barré syndrome. | lld:pubmed |
| pubmed-article:11004133 | pubmed:affiliation | Department of Neurology, Chiba University School of Medicine, Chiba, Japan. morim@olive.ocn.ne.jp | lld:pubmed |
| pubmed-article:11004133 | pubmed:publicationType | Journal Article | lld:pubmed |
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