Source:http://linkedlifedata.com/resource/pubmed/id/11004133
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| Predicate | Object |
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| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2000-10-27
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| pubmed:abstractText |
It has been reported recently that Haemophilus influenzae can elicit an axonal form of Guillain-Barré syndrome. To investigate the incidence and features of H. influenzae-related Guillain-Barré syndrome, anti-H. influenzae antibody titres were measured by enzyme-linked immunosorbent assay (ELISA) in 46 consecutive Japanese patients with Guillain-Barré syndrome, 49 normal controls, 24 patients with multiple sclerosis and 27 patients with amyotrophic lateral sclerosis (ALS). Whole bacteria of non-encapsulated (non-typable) H. influenzae isolated from one of the Guillain-Barré syndrome patients was the antigen used. Elevated anti-H. influenzae antibodies for two or three classes of IgG, IgM and IgA were found in six (13%) Guillain-Barré syndrome patients, but not in the normal controls and patients with multiple sclerosis or ALS. The incidence was significantly higher in patients with Guillain-Barré syndrome than in the normal controls (P = 0.01) and patients with multiple sclerosis or ALS (P = 0.009). Western blot analysis confirmed that the H. influenzae-positive patients' IgG recognized the lipopolysaccharides of H. influenzae. Guillain-Barré syndrome patients with anti-H. influenzae antibodies showed relatively uniform clinical and laboratory features: prodromal respiratory infection, less frequent cranial and sensory nerve involvement, pure motor axonal degeneration on electrophysiology, and positivity for IgG anti-GM1 antibodies. Although the features were similar to those in Guillain-Barré syndrome patients infected by Campylobacter jejuni, the recoveries seemed to be better in patients with H. influenzae-related Guillain-Barré syndrome. It is concluded that a form of Guillain-Barré syndrome occurs after respiratory infection by H. influenzae in the Japanese population. A particular strain of non-typable H. influenzae has a ganglioside GM1-like structure and elicits axonal Guillain-Barré syndrome similar to C. jejuni-related Guillain-Barré syndrome.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/G(M1) Ganglioside,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0006-8950
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
123 ( Pt 10)
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2171-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11004133-Adult,
pubmed-meshheading:11004133-Aged,
pubmed-meshheading:11004133-Aged, 80 and over,
pubmed-meshheading:11004133-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:11004133-Antibodies, Bacterial,
pubmed-meshheading:11004133-Autoantibodies,
pubmed-meshheading:11004133-Axons,
pubmed-meshheading:11004133-Case-Control Studies,
pubmed-meshheading:11004133-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:11004133-Female,
pubmed-meshheading:11004133-G(M1) Ganglioside,
pubmed-meshheading:11004133-Guillain-Barre Syndrome,
pubmed-meshheading:11004133-Haemophilus Infections,
pubmed-meshheading:11004133-Haemophilus influenzae,
pubmed-meshheading:11004133-Humans,
pubmed-meshheading:11004133-Immunoglobulin A,
pubmed-meshheading:11004133-Immunoglobulin G,
pubmed-meshheading:11004133-Immunoglobulin M,
pubmed-meshheading:11004133-Male,
pubmed-meshheading:11004133-Multiple Sclerosis,
pubmed-meshheading:11004133-Retrospective Studies
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| pubmed:year |
2000
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| pubmed:articleTitle |
Haemophilus influenzae infection and Guillain-Barré syndrome.
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| pubmed:affiliation |
Department of Neurology, Chiba University School of Medicine, Chiba, Japan. morim@olive.ocn.ne.jp
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| pubmed:publicationType |
Journal Article
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