| pubmed-article:11001930 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11001930 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:11001930 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:11001930 | lifeskim:mentions | umls-concept:C0008654 | lld:lifeskim |
| pubmed-article:11001930 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:11001930 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:11001930 | lifeskim:mentions | umls-concept:C1456377 | lld:lifeskim |
| pubmed-article:11001930 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:11001930 | lifeskim:mentions | umls-concept:C0243902 | lld:lifeskim |
| pubmed-article:11001930 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:11001930 | pubmed:dateCreated | 2000-10-18 | lld:pubmed |
| pubmed-article:11001930 | pubmed:abstractText | Although the varepsilon4 allele of the apolipoprotein E gene appears as an important biological marker for Alzheimer's disease (AD) susceptibility, other genetic determinants are clearly implicated in the AD process. Here, we propose that a genetic variation in the transcriptional factor LBP-1c/CP2/LSF gene, located close to the LRP locus, is a genetic susceptibility factor for AD. We report an association between a non-coding polymorphism (G-->A) in the 3'-untranslated region of this gene and sporadic AD in French and British populations and a similar trend in a North American population. The combined analysis of these three independent populations provides evidence of a protective effect of the A allele (OR = 0.58, 95% CI 0.44-0.75). We describe a potential biologically relevant role for the A allele whereby it reduces binding to nuclear protein(s). The absence of the A allele was associated with a lower LBP-1c/CP2/LSF gene expression in lymphocytes from AD cases compared with controls. Our data suggest that polymorphic variation in the implication of the LBP-1c/CP2/LSF gene may be important for the pathogenesis of AD, particularly since LBP-1c/CP2/LSF interacts with proteins such as GSKbeta, Fe65 and certain factors involved in the inflammatory response. | lld:pubmed |
| pubmed-article:11001930 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11001930 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11001930 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11001930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11001930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11001930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11001930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11001930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11001930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11001930 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11001930 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11001930 | pubmed:issn | 0964-6906 | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:HardyJJ | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:PasquierFF | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:MannD MDM | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:LambertJ CJC | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:HarrisJ MJM | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:CummingsAA | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:FrigardBB | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:Chartier-Harl... | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:St ClairDD | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:LendonC LCL | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:CoatesJJ | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:AmouyelPP | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:CotterNN | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:GoumidiLL | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:VrièzeF WFW | lld:pubmed |
| pubmed-article:11001930 | pubmed:author | pubmed-author:GaillacMM | lld:pubmed |
| pubmed-article:11001930 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11001930 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:11001930 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:11001930 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11001930 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11001930 | pubmed:pagination | 2275-80 | lld:pubmed |
| pubmed-article:11001930 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11001930 | pubmed:meshHeading | pubmed-meshheading:11001930... | lld:pubmed |
| pubmed-article:11001930 | pubmed:meshHeading | pubmed-meshheading:11001930... | lld:pubmed |
| pubmed-article:11001930 | pubmed:meshHeading | pubmed-meshheading:11001930... | lld:pubmed |
| pubmed-article:11001930 | pubmed:meshHeading | pubmed-meshheading:11001930... | lld:pubmed |
| pubmed-article:11001930 | pubmed:meshHeading | pubmed-meshheading:11001930... | lld:pubmed |
| pubmed-article:11001930 | pubmed:meshHeading | pubmed-meshheading:11001930... | lld:pubmed |
| pubmed-article:11001930 | pubmed:meshHeading | pubmed-meshheading:11001930... | lld:pubmed |
| pubmed-article:11001930 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11001930 | pubmed:articleTitle | The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease. | lld:pubmed |
| pubmed-article:11001930 | pubmed:affiliation | INSERM U508, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cédex, France. | lld:pubmed |
| pubmed-article:11001930 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11001930 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:11001930 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| entrez-gene:7024 | entrezgene:pubmed | pubmed-article:11001930 | lld:entrezgene |
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