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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2000-10-18
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pubmed:abstractText |
Although the varepsilon4 allele of the apolipoprotein E gene appears as an important biological marker for Alzheimer's disease (AD) susceptibility, other genetic determinants are clearly implicated in the AD process. Here, we propose that a genetic variation in the transcriptional factor LBP-1c/CP2/LSF gene, located close to the LRP locus, is a genetic susceptibility factor for AD. We report an association between a non-coding polymorphism (G-->A) in the 3'-untranslated region of this gene and sporadic AD in French and British populations and a similar trend in a North American population. The combined analysis of these three independent populations provides evidence of a protective effect of the A allele (OR = 0.58, 95% CI 0.44-0.75). We describe a potential biologically relevant role for the A allele whereby it reduces binding to nuclear protein(s). The absence of the A allele was associated with a lower LBP-1c/CP2/LSF gene expression in lymphocytes from AD cases compared with controls. Our data suggest that polymorphic variation in the implication of the LBP-1c/CP2/LSF gene may be important for the pathogenesis of AD, particularly since LBP-1c/CP2/LSF interacts with proteins such as GSKbeta, Fe65 and certain factors involved in the inflammatory response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0964-6906
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pubmed:author |
pubmed-author:AmouyelPP,
pubmed-author:Chartier-HarlinM CMC,
pubmed-author:CoatesJJ,
pubmed-author:CotterNN,
pubmed-author:CummingsAA,
pubmed-author:FrigardBB,
pubmed-author:GaillacMM,
pubmed-author:GoumidiLL,
pubmed-author:HardyJJ,
pubmed-author:HarrisJ MJM,
pubmed-author:LambertJ CJC,
pubmed-author:LendonC LCL,
pubmed-author:MannD MDM,
pubmed-author:PasquierFF,
pubmed-author:St ClairDD,
pubmed-author:VrièzeF WFW
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2275-80
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11001930-3' Untranslated Regions,
pubmed-meshheading:11001930-Aged,
pubmed-meshheading:11001930-Aged, 80 and over,
pubmed-meshheading:11001930-Alzheimer Disease,
pubmed-meshheading:11001930-Chromosomes, Human, Pair 12,
pubmed-meshheading:11001930-DNA-Binding Proteins,
pubmed-meshheading:11001930-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:11001930-Exons,
pubmed-meshheading:11001930-Female,
pubmed-meshheading:11001930-Genotype,
pubmed-meshheading:11001930-Humans,
pubmed-meshheading:11001930-Male,
pubmed-meshheading:11001930-Polymorphism, Genetic,
pubmed-meshheading:11001930-Promoter Regions, Genetic,
pubmed-meshheading:11001930-Protein Binding,
pubmed-meshheading:11001930-RNA, Messenger,
pubmed-meshheading:11001930-RNA-Binding Proteins,
pubmed-meshheading:11001930-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11001930-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease.
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pubmed:affiliation |
INSERM U508, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cédex, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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