Linked Life Data

11001569

Source:http://linkedlifedata.com/resource/pubmed/id/11001569

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2000-9-29
pubmed:abstractText
Sphingolipid second messengers, such as ceramide and sphingosine-1-phosphate, signal proliferation, differentiation and death in mammalian cells. The object of this article is to highlight the potential impact of this new information on the study of female and male gonadal development and function. Since the generation of competent gametes by both sexes is precisely regulated by maturational (meiotic) and apoptotic (quality-control) checkpoints, it is proposed that lipid signaling molecules serve as important contributors to the regulation of gametogenesis. The function of sphingolipid molecules in mediating stress- or damage-induced apoptosis in the germ line, an event most-likely associated with impaired gonadal function and infertility, is also discussed. Collectively, these areas represent exciting research directions that may ultimately lead to the development of new therapeutics to coordinate and control fertility in males and females.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0009-3084
pubmed:author
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-55
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Sphingolipid signaling in gonadal development and function.
pubmed:affiliation
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA. jtilly@partners.org
pubmed:publicationType
Journal Article, Review