Linked Life Data

11000344

Source:http://linkedlifedata.com/resource/pubmed/id/11000344

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-10-19
pubmed:abstractText
There is an incomplete understanding of the contribution of early growth to bone accrual in childhood. The aims of this longitudinal study were to examine the association between growth variables at birth, 1 month, and 8 years and bone density in prepubertal children. Weight and length at both birth and 1 month of age were measured in 1988 as part of a prospective study for sudden infant death syndrome. A total of 330 children (47%) and 278 of their mothers were then contacted in 1996 for measurement of anthropometrics and bone density. Birth weight, birth length, and length gain (but not weight gain) in the first month all made significant contributions to areal bone density (BMD, g/cm(2)) at all sites at age 8 even after taking into account subsequent weight and height gain (model R(2) 14-39% depending on variable and site). Adjustment for potential environmental confounders did not alter these findings, however, adjustment for maternal BMD markedly reduced the early life associations (particularly for birth weight). Though early life factors were weakly associated with bone mineral apparent density (BMAD, g/cm(3)) in correlation analysis, subsequent height and weight gain were the only significant independent contributors to BMAD. In conclusion, early life anthropometrics make little contribution to BMAD (other than through their correlation with later growth) but make significant independent contributions to BMD suggesting that the growth trajectory of bone is determined very early in life. In addition, the contribution of body size at birth to bone growth in early life appears to be mediated by genetic factors although it is possible that it may be mediated by poorly measured or as yet unidentified determinants of body size at birth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0171-967X
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
304-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Birth weight, birth length, and bone density in prepubertal children: evidence for an association that may be mediated by genetic factors.
pubmed:affiliation
Menzies Centre for Population Health Research, GPO Box 252-23, Hobart, Tasmania, Australia, 7001.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't