Source:http://linkedlifedata.com/resource/pubmed/id/11000047
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2000-11-6
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pubmed:abstractText |
Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9-96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC(50) values 627 nM (K1), 718 nM (T9-96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0163-3864
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1306-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11000047-Animals,
pubmed-meshheading:11000047-Antimalarials,
pubmed-meshheading:11000047-Asteraceae,
pubmed-meshheading:11000047-Drug Screening Assays, Antitumor,
pubmed-meshheading:11000047-Humans,
pubmed-meshheading:11000047-Naphthoquinones,
pubmed-meshheading:11000047-Plant Extracts,
pubmed-meshheading:11000047-Plants, Medicinal,
pubmed-meshheading:11000047-Plasmodium falciparum,
pubmed-meshheading:11000047-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum.
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pubmed:affiliation |
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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