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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2000-10-17
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pubmed:abstractText |
The cellular mechanisms that may contribute to epilepsy in resected human cortical dysplasia (CD) were compared with the in utero radiated rat CD model. In human and rat focal hippocampal epilepsy, postsynaptic N-methyl-D-aspartate receptors are up-regulated and presynaptic axon collaterals hyperinnervate them. We hypothesized that in both human and rat CD: (a) the N-methyl-D-aspartate receptor subunits NR1 and NR2A/B would be increased and coassembled, and (b) aberrant axons would be in regions of CD.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0013-9580
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41 Suppl 6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S76-81
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10999524-Abnormalities, Radiation-Induced,
pubmed-meshheading:10999524-Animals,
pubmed-meshheading:10999524-Cerebral Cortex,
pubmed-meshheading:10999524-Electroencephalography,
pubmed-meshheading:10999524-Epilepsies, Partial,
pubmed-meshheading:10999524-Epilepsy,
pubmed-meshheading:10999524-Fluorescent Antibody Technique,
pubmed-meshheading:10999524-Gamma Rays,
pubmed-meshheading:10999524-Histocytochemistry,
pubmed-meshheading:10999524-Humans,
pubmed-meshheading:10999524-Immunoblotting,
pubmed-meshheading:10999524-Microscopy, Confocal,
pubmed-meshheading:10999524-Mossy Fibers, Hippocampal,
pubmed-meshheading:10999524-Neuronal Plasticity,
pubmed-meshheading:10999524-Precipitin Tests,
pubmed-meshheading:10999524-Pyramidal Cells,
pubmed-meshheading:10999524-Rats,
pubmed-meshheading:10999524-Receptors, N-Methyl-D-Aspartate
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pubmed:year |
2000
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pubmed:articleTitle |
Brain plasticity and cellular mechanisms of epileptogenesis in human and experimental cortical dysplasia.
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pubmed:affiliation |
Department of Neurosciences, The Cleveland Clinic Foundation, Ohio 44195, USA. babbt@ccf.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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