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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2000-12-26
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pubmed:abstractText |
To investigate the role of the amide group of (-)-indolactam-V (1) on PKC binding, we synthesized (-)-indothiolactam-V (2), a new thioamide analogue of 1, by microbial conversion using Streptomyces blastmyceticum. Compounds 2 and 1 showed similar binding affinities to conventional PKCs but 2 had lower affinities to novel PKCs, suggesting that novel PKCs recognize amide modifications more effectively than conventional PKCs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2087-90
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10999477-Binding, Competitive,
pubmed-meshheading:10999477-Carcinogens,
pubmed-meshheading:10999477-Enzyme Activation,
pubmed-meshheading:10999477-Indoles,
pubmed-meshheading:10999477-Isoenzymes,
pubmed-meshheading:10999477-Lactams,
pubmed-meshheading:10999477-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10999477-Peptide Fragments,
pubmed-meshheading:10999477-Phorbol 12,13-Dibutyrate,
pubmed-meshheading:10999477-Protein Binding,
pubmed-meshheading:10999477-Protein Kinase C,
pubmed-meshheading:10999477-Thioamides
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pubmed:year |
2000
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pubmed:articleTitle |
Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V.
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pubmed:affiliation |
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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