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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2000-12-26
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pubmed:abstractText |
Inhibitors of the MAP kinase p38 are potentially useful for the treatment of arthritis and osteoporosis. Several 2,3-dichlorophenyl ureas were identified as small-molecule inhibitors of p38 by a combinatorial chemistry effort. Optimization for cellular potency led to the discovery of a new class of potent and selective p38 kinase inhibitors, exemplified by the 1-phenyl-5-pyrazolyl urea 7 (IC50 = 13 nM).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BhargavaAA,
pubmed-author:BrennanCC,
pubmed-author:DumasJJ,
pubmed-author:Hatoum-MokdadHH,
pubmed-author:HousleyT JTJ,
pubmed-author:JohnsonJ SJS,
pubmed-author:LowingerT BTB,
pubmed-author:MonahanM KMK,
pubmed-author:NateroRR,
pubmed-author:RangesG EGE,
pubmed-author:RiedlBB,
pubmed-author:SchoenleberRR,
pubmed-author:ScottW JWJ,
pubmed-author:ShrikhandeAA,
pubmed-author:SibleyRR,
pubmed-author:TurnerTT,
pubmed-author:WilhelmS MSM
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2051-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10999468-Antirheumatic Agents,
pubmed-meshheading:10999468-Combinatorial Chemistry Techniques,
pubmed-meshheading:10999468-Enzyme Inhibitors,
pubmed-meshheading:10999468-Heterocyclic Compounds,
pubmed-meshheading:10999468-Humans,
pubmed-meshheading:10999468-Hydrocarbons, Chlorinated,
pubmed-meshheading:10999468-Inhibitory Concentration 50,
pubmed-meshheading:10999468-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10999468-Osteoporosis,
pubmed-meshheading:10999468-Phenylurea Compounds,
pubmed-meshheading:10999468-Pyrazoles,
pubmed-meshheading:10999468-Solubility,
pubmed-meshheading:10999468-Structure-Activity Relationship,
pubmed-meshheading:10999468-Urea,
pubmed-meshheading:10999468-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2000
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pubmed:articleTitle |
1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors.
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pubmed:affiliation |
Department of Chemistry Research, Bayer Research Center, West Haven, CT 06516, USA. jacques.dumas.b@bayer.com
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pubmed:publicationType |
Journal Article
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