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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-10-18
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pubmed:abstractText |
Here we report that the Schizosaccharomyces pombe Rad9 (SpRad9) protein contains a group of amino acids with similarity to the Bcl-2 homology 3 death domain, which is required for SpRad9 interaction with human Bcl-2 and apoptosis induction in human cells. Overexpression of Bcl-2 in S. pombe inhibits cell growth independently of rad9, but enhances resistance of rad9-null cells to methyl methanesulfonate, ultraviolet and ionizing radiation. These observations suggest that SpRad9 may represent the first member of the Bcl-2 protein family identified in yeast, though the cell death pathways in S. pombe may differ from those found in mammals.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
481
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
122-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10996309-Apoptosis,
pubmed-meshheading:10996309-Binding Sites,
pubmed-meshheading:10996309-Cell Cycle Proteins,
pubmed-meshheading:10996309-Cell Division,
pubmed-meshheading:10996309-Cell Line,
pubmed-meshheading:10996309-Conserved Sequence,
pubmed-meshheading:10996309-DNA Damage,
pubmed-meshheading:10996309-Evolution, Molecular,
pubmed-meshheading:10996309-Gene Deletion,
pubmed-meshheading:10996309-Gene Expression,
pubmed-meshheading:10996309-Genes, Suppressor,
pubmed-meshheading:10996309-Humans,
pubmed-meshheading:10996309-Methyl Methanesulfonate,
pubmed-meshheading:10996309-Mutagens,
pubmed-meshheading:10996309-Protein Binding,
pubmed-meshheading:10996309-Protein Structure, Tertiary,
pubmed-meshheading:10996309-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10996309-Schizosaccharomyces,
pubmed-meshheading:10996309-Thiamine,
pubmed-meshheading:10996309-Two-Hybrid System Techniques
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pubmed:year |
2000
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pubmed:articleTitle |
Schizosaccharomyces pombe Rad9 contains a BH3-like region and interacts with the anti-apoptotic protein Bcl-2.
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pubmed:affiliation |
Drug Discovery Program, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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