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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-10-12
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pubmed:abstractText |
Expression of alpha4 integrin by auto-reactive T cells is critical for their ability to induce EAE, an autoimmune disease of the central nervous system in mice, used as a model to study human multiple sclerosis. Having previously identified one role for alpha4 integrin in adhesion-mediated induction of matrix metalloproteinase-2 (MMP-2), an enzyme that degrades the subendothelial basement membrane matrix, we investigated independent roles for MMP-2 and alpha4 integrin during EAE. The data suggest that expression of alpha4 integrin by auto-reactive T cells is important not only in mediating MMP-2 induction to facilitate entry into the CNS, but also plays a role in maintaining residency within the CNS.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-31
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10996214-Animals,
pubmed-meshheading:10996214-Antigens, CD,
pubmed-meshheading:10996214-Autoantigens,
pubmed-meshheading:10996214-Brain,
pubmed-meshheading:10996214-Cell Movement,
pubmed-meshheading:10996214-Clone Cells,
pubmed-meshheading:10996214-Dipeptides,
pubmed-meshheading:10996214-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:10996214-Endothelium, Vascular,
pubmed-meshheading:10996214-Integrin alpha4,
pubmed-meshheading:10996214-Matrix Metalloproteinase 2,
pubmed-meshheading:10996214-Mice,
pubmed-meshheading:10996214-Mice, Inbred Strains,
pubmed-meshheading:10996214-Mice, Transgenic,
pubmed-meshheading:10996214-Multiple Sclerosis,
pubmed-meshheading:10996214-Protease Inhibitors,
pubmed-meshheading:10996214-Rats,
pubmed-meshheading:10996214-T-Lymphocytes
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pubmed:year |
2000
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pubmed:articleTitle |
Distinct roles for matrix metalloproteinase-2 and alpha4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis.
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pubmed:affiliation |
Department of Pathology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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