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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-10-30
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pubmed:abstractText |
Astrogliosis is a hallmark of prion diseases. Finding ways of inhibiting astrocyte proliferation may be beneficial to treating these diseases. PrP106-126 a peptide fragment of the prion protein induces proliferation of astrocytes. The mechanism of its action was studied in detail. Induction of astrocyte proliferation in culture requires cytokines interleukin-1 and interleukin-6 released from microglia in the presence of PrP106-126. However, the increased release of these cytokines is insufficient without direct effects of PrP106-126 on astrocytes. PrP106-126 induces increased progression through the cell cycle to late G1 and enhances the level of both p53 and phosphorylated ERKs in astrocytes. PrP106-126-induced proliferation of astrocytes in culture can be inhibited by antibodies to cytokines or by MEK inhibitors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1044-7431
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-32
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10995549-Animals,
pubmed-meshheading:10995549-Astrocytes,
pubmed-meshheading:10995549-Cell Cycle,
pubmed-meshheading:10995549-Cell Division,
pubmed-meshheading:10995549-Cells, Cultured,
pubmed-meshheading:10995549-Coculture Techniques,
pubmed-meshheading:10995549-Gliosis,
pubmed-meshheading:10995549-Mice,
pubmed-meshheading:10995549-Microglia,
pubmed-meshheading:10995549-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10995549-Peptide Fragments,
pubmed-meshheading:10995549-Phosphorylation,
pubmed-meshheading:10995549-Polymerase Chain Reaction,
pubmed-meshheading:10995549-Prion Diseases,
pubmed-meshheading:10995549-Prions,
pubmed-meshheading:10995549-Receptors, Interleukin-1,
pubmed-meshheading:10995549-Receptors, Interleukin-6,
pubmed-meshheading:10995549-Signal Transduction
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pubmed:year |
2000
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pubmed:articleTitle |
A model for the mechanism of astrogliosis in prion disease.
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pubmed:affiliation |
Department of Biochemistry, Cambridge University, Cambridge, CB2 1QW, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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