Linked Life Data

10994852

Source:http://linkedlifedata.com/resource/pubmed/id/10994852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2000-10-3
pubmed:abstractText
An unexpected decrease of extracellular space (ECS) tortuosity was recently reported in thick (1,000 microm) ischemic slices using radiotracers. The current study shows that the tortuosity in thick slices from rat neocortex can increase or decrease depending on experimental conditions, whereas ECS volume fraction remains diminished to approximately 10%. Using diffusion of tetramethylammonium, it was found that tortuosity rose from a normoxic value of 1.66 to 1.99 in thick slices. However, tortuosity dropped to 1.54 when dextran (70,000 molecular weight) was added to the bathing medium. The current results show that dextran enhances diffusion in thick ischemic slices without increasing the size of the ECS.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0271-678X
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1306-10
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Dextran decreases extracellular tortuosity in thick-slice ischemia model.
pubmed:affiliation
Department of Physiology and Neuroscience, New York University School of Medicine, New York 10016, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.