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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-10-30
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pubmed:abstractText |
Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T lymphocyte-mediated disease of the central nervous system (CNS) characterized by mononuclear cell infiltration, demyelination, and paralysis. We previously demonstrated a role for chemokines in acute and relapsing EAE pathogenesis. Presently, we investigated the role of CC chemokine receptor 2 (CCR2) in acute EAE. CCR2(-/-) mice did not develop clinical EAE or CNS histopathology, and showed a significant reduction in T cell- and CNS-infiltrating CD45(high)F4/80(+) monocyte subpopulations. Peripheral lymphocytes from CCR2(-/-) mice produced comparable levels of interferon-gamma (IFN-gamma) and interleukin (IL)-2 in response to antigen-specific restimulation when compared with control mice. Adoptively transferred myelin oligodendrocyte glycoprotein 35-55-specific T cells lacking expression of CCR2 were able to induce EAE, whereas CCR2(-/-) recipients of wild-type T cells failed to develop disease. These results suggest that CCR2 expression on host-derived mononuclear cells is critical for disease induction.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-10208497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-10329593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-10359810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-10438957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-10553079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-10602404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-10699158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-10714678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-1538783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-1696331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-2033653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-7544693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-7722289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-8080842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-8097758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-8662823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-8823379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-9024663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-9183256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-9254664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-9342361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-9362535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-9366570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-9394808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-9697831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-9743321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10993920-9916884
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ccr2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin-Associated Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/myelin oligodendrocyte glycoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
192
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
899-905
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10993920-Amino Acid Sequence,
pubmed-meshheading:10993920-Animals,
pubmed-meshheading:10993920-Cells, Cultured,
pubmed-meshheading:10993920-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:10993920-Interferon-gamma,
pubmed-meshheading:10993920-Interleukin-2,
pubmed-meshheading:10993920-Lymphocyte Activation,
pubmed-meshheading:10993920-Lymphocytes,
pubmed-meshheading:10993920-Mice,
pubmed-meshheading:10993920-Mice, Knockout,
pubmed-meshheading:10993920-Molecular Sequence Data,
pubmed-meshheading:10993920-Myelin Proteins,
pubmed-meshheading:10993920-Myelin-Associated Glycoprotein,
pubmed-meshheading:10993920-Oligodendroglia,
pubmed-meshheading:10993920-Peptide Fragments,
pubmed-meshheading:10993920-Receptors, CCR2,
pubmed-meshheading:10993920-Receptors, Chemokine,
pubmed-meshheading:10993920-Reference Values,
pubmed-meshheading:10993920-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2000
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pubmed:articleTitle |
CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis.
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pubmed:affiliation |
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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