| pubmed-article:10993800 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10993800 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:10993800 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:10993800 | lifeskim:mentions | umls-concept:C2339371 | lld:lifeskim |
| pubmed-article:10993800 | lifeskim:mentions | umls-concept:C0009647 | lld:lifeskim |
| pubmed-article:10993800 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10993800 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:10993800 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:10993800 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10993800 | pubmed:dateCreated | 2000-10-12 | lld:pubmed |
| pubmed-article:10993800 | pubmed:abstractText | We investigated the roles of beta(1)- and beta(2)-receptors (beta-AR) in adrenergic enhancement of L-type Ca(2+) current (I(CaL)) in canine ventricular myocytes. Isoproterenol and l-norepinephrine produced a monophasic and a biphasic concentration-I(CaL) relationship (CR), respectively. alpha(1)-AR inhibition with prazosin and beta(2)-AR stimulation with zinterol or l-epinephrine shifted the CR of l-norepinephrine leftward. Zinterol (50 nM) and l-epinephrine (10 nM), but not prazosin, altered the biphasic CR of l-norepinephrine to a monophasic CR. Zinterol and l-epinephrine applied after l-norepinephrine had no effect on I(CaL). beta(2)-AR inhibition with ICI-118551 reduced the E(max) of isoproterenol and l-norepinephrine by 60% and abolished the augmentation of l-norepinephrine by zinterol and l-epinephrine. Carbachol (100 nM) modestly reduced the I(CaL) response to beta(1)-AR stimulation but abolished the enhancement via beta(2)-AR. Zinterol augmented the enhancement of I(CaL) by forskolin, IBMX, and theophylline, but not in the presence of CGP-20712A. We conclude that selective beta(2)-AR stimulation does not increase I(CaL) but enhances adenylyl cyclase activity when stimulated via beta(1)-AR and with forskolin. beta(2)-AR activity preconditions adenylyl cyclase for beta(1)-AR stimulation. | lld:pubmed |
| pubmed-article:10993800 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10993800 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993800 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10993800 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10993800 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:10993800 | pubmed:author | pubmed-author:LazzaraRR | lld:pubmed |
| pubmed-article:10993800 | pubmed:author | pubmed-author:LIT | lld:pubmed |
| pubmed-article:10993800 | pubmed:author | pubmed-author:SzaboBB | lld:pubmed |
| pubmed-article:10993800 | pubmed:author | pubmed-author:NagykaldiZZ | lld:pubmed |
| pubmed-article:10993800 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10993800 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:10993800 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10993800 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10993800 | pubmed:pagination | H1329-37 | lld:pubmed |
| pubmed-article:10993800 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:10993800 | pubmed:meshHeading | pubmed-meshheading:10993800... | lld:pubmed |
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| pubmed-article:10993800 | pubmed:meshHeading | pubmed-meshheading:10993800... | lld:pubmed |
| pubmed-article:10993800 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10993800 | pubmed:articleTitle | Conditioning of beta(1)-adrenoceptor effect via beta(2)-subtype on L-type Ca(2+) current in canine ventricular myocytes. | lld:pubmed |
| pubmed-article:10993800 | pubmed:affiliation | Section of Endocrinology, Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA. | lld:pubmed |
| pubmed-article:10993800 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10993800 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10993800 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
