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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-10-12
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pubmed:abstractText |
Cardiac hypertrophy and function were studied 6 wk after constriction of the thoracic aorta (TAC) in transgenic (TG) mice expressing constitutively active mutant alpha(1B)-adrenergic receptors (ARs) in the heart. Hearts from sham-operated TG animals and nontransgenic littermates (WT) were similar in size, but hearts from TAC/TG mice were larger than those from TAC/WT mice, and atrial natriuretic peptide mRNA expression was also higher. Lung weight was markedly increased in TAC/TG animals, and the incidence of left atrial thrombus formation was significantly higher. Ventricular contractility in anesthetized animals, although it was increased in TAC/WT hearts, was unchanged in TAC/TG hearts, implying cardiac decompensation and progression to failure in TG mice. There was no increase in alpha(1A)-AR mRNA expression in TAC/WT hearts, and expression was significantly reduced in TAC/TG hearts. These findings show that cardiac expression of constitutively actively mutant alpha(1B)-ARs is detrimental in terms of hypertrophy and cardiac function after pressure overload and that increased alpha(1A)-AR mRNA expression is not a feature of the hypertrophic response in this murine model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Atrial Natriuretic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Cardiac Myosins,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Light Chains,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/myosin light chain 2
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0363-6135
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
H1079-86
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10993770-Adrenergic alpha-1 Receptor Antagonists,
pubmed-meshheading:10993770-Adrenergic alpha-Antagonists,
pubmed-meshheading:10993770-Animals,
pubmed-meshheading:10993770-Aorta, Thoracic,
pubmed-meshheading:10993770-Atrial Natriuretic Factor,
pubmed-meshheading:10993770-Binding, Competitive,
pubmed-meshheading:10993770-Blood Pressure,
pubmed-meshheading:10993770-Cardiac Myosins,
pubmed-meshheading:10993770-Cardiomegaly,
pubmed-meshheading:10993770-Constriction, Pathologic,
pubmed-meshheading:10993770-Down-Regulation,
pubmed-meshheading:10993770-Heart,
pubmed-meshheading:10993770-Lung,
pubmed-meshheading:10993770-Mice,
pubmed-meshheading:10993770-Mice, Inbred Strains,
pubmed-meshheading:10993770-Mice, Transgenic,
pubmed-meshheading:10993770-Myocardium,
pubmed-meshheading:10993770-Myosin Light Chains,
pubmed-meshheading:10993770-Organ Size,
pubmed-meshheading:10993770-Pressure,
pubmed-meshheading:10993770-Promoter Regions, Genetic,
pubmed-meshheading:10993770-RNA, Messenger,
pubmed-meshheading:10993770-Radioligand Assay,
pubmed-meshheading:10993770-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:10993770-Thrombosis
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pubmed:year |
2000
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pubmed:articleTitle |
Adverse effects of constitutively active alpha(1B)-adrenergic receptors after pressure overload in mouse hearts.
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pubmed:affiliation |
Cellular Biochemistry Laboratory, Baker Medical Research Institute, Prahran 3181, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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