| pubmed-article:10993761 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10993761 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:10993761 | lifeskim:mentions | umls-concept:C1522564 | lld:lifeskim |
| pubmed-article:10993761 | lifeskim:mentions | umls-concept:C0215825 | lld:lifeskim |
| pubmed-article:10993761 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:10993761 | lifeskim:mentions | umls-concept:C0597198 | lld:lifeskim |
| pubmed-article:10993761 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10993761 | lifeskim:mentions | umls-concept:C2346689 | lld:lifeskim |
| pubmed-article:10993761 | lifeskim:mentions | umls-concept:C1550025 | lld:lifeskim |
| pubmed-article:10993761 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10993761 | pubmed:dateCreated | 2000-10-12 | lld:pubmed |
| pubmed-article:10993761 | pubmed:abstractText | Myocardial actions of the vasodilator peptide adrenomedullin (ADM) in the intact animal are unknown. Negative and positive inotropic actions have been reported in ex vivo experiments. Myocardial and load-altering actions of ADM in dogs before and after development of heart failure were studied. With controlled heart rate (atrial pacing) and after beta-blockade, ADM was administered to five normal dogs in doses of 20 ng. kg(-1). min(-1) iv, 100 ng. kg(-1). min(-1) iv, and 200 ng. kg(-1). min(-1) into the left ventricle (LV). LV peak systolic pressure and end-systolic volume decreased with each dose of ADM. End-systolic pressure decreased with the two higher doses. At the highest dose, arterial elastance and the time constant of LV isovolumic relaxation (tau) decreased, and LV end-systolic elastance (E(es)) increased. LV end-diastolic pressure and volume were unchanged. In five additional normal dogs receiving only the highest dose of ADM (200 ng. kg(-1). min(-1) intra-LV), to control for increased heart rate and sympathetic activation observed with the cumulative infusion, ADM produced arterial vasodilation but no change in E(es) or tau. In four dogs with pacing-induced heart failure, ADM (200 ng. kg(-1). min(-1) intra-LV) was without effect on tau, E(es), and systolic or diastolic pressure and volume. In vivo, ADM appears to be a selective arterial dilator without inotropic or lusitropic effects. The vasodilatory actions are attenuated in heart failure. | lld:pubmed |
| pubmed-article:10993761 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10993761 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993761 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10993761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10993761 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10993761 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10993761 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:10993761 | pubmed:author | pubmed-author:BurnettJ... | lld:pubmed |
| pubmed-article:10993761 | pubmed:author | pubmed-author:MeyerD MDM | lld:pubmed |
| pubmed-article:10993761 | pubmed:author | pubmed-author:RedfieldM MMM | lld:pubmed |
| pubmed-article:10993761 | pubmed:author | pubmed-author:JougasakiMM | lld:pubmed |
| pubmed-article:10993761 | pubmed:author | pubmed-author:LainchburyJ... | lld:pubmed |
| pubmed-article:10993761 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10993761 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:10993761 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10993761 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10993761 | pubmed:pagination | H1000-6 | lld:pubmed |
| pubmed-article:10993761 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10993761 | pubmed:meshHeading | pubmed-meshheading:10993761... | lld:pubmed |
| pubmed-article:10993761 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10993761 | pubmed:articleTitle | Effects of adrenomedullin on load and myocardial performance in normal and heart-failure dogs. | lld:pubmed |
| pubmed-article:10993761 | pubmed:affiliation | Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Physiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. | lld:pubmed |
| pubmed-article:10993761 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10993761 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10993761 | lld:pubmed |
