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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-10-12
pubmed:abstractText
Myocardial actions of the vasodilator peptide adrenomedullin (ADM) in the intact animal are unknown. Negative and positive inotropic actions have been reported in ex vivo experiments. Myocardial and load-altering actions of ADM in dogs before and after development of heart failure were studied. With controlled heart rate (atrial pacing) and after beta-blockade, ADM was administered to five normal dogs in doses of 20 ng. kg(-1). min(-1) iv, 100 ng. kg(-1). min(-1) iv, and 200 ng. kg(-1). min(-1) into the left ventricle (LV). LV peak systolic pressure and end-systolic volume decreased with each dose of ADM. End-systolic pressure decreased with the two higher doses. At the highest dose, arterial elastance and the time constant of LV isovolumic relaxation (tau) decreased, and LV end-systolic elastance (E(es)) increased. LV end-diastolic pressure and volume were unchanged. In five additional normal dogs receiving only the highest dose of ADM (200 ng. kg(-1). min(-1) intra-LV), to control for increased heart rate and sympathetic activation observed with the cumulative infusion, ADM produced arterial vasodilation but no change in E(es) or tau. In four dogs with pacing-induced heart failure, ADM (200 ng. kg(-1). min(-1) intra-LV) was without effect on tau, E(es), and systolic or diastolic pressure and volume. In vivo, ADM appears to be a selective arterial dilator without inotropic or lusitropic effects. The vasodilatory actions are attenuated in heart failure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0363-6135
pubmed:author
pubmed:issnType
Print
pubmed:volume
279
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H1000-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:10993761-Adrenomedullin, pubmed-meshheading:10993761-Animals, pubmed-meshheading:10993761-Blood Pressure, pubmed-meshheading:10993761-Cardiac Pacing, Artificial, pubmed-meshheading:10993761-Cyclic AMP, pubmed-meshheading:10993761-Disease Models, Animal, pubmed-meshheading:10993761-Dogs, pubmed-meshheading:10993761-Dose-Response Relationship, Drug, pubmed-meshheading:10993761-Epinephrine, pubmed-meshheading:10993761-Heart, pubmed-meshheading:10993761-Heart Failure, pubmed-meshheading:10993761-Heart Rate, pubmed-meshheading:10993761-Infusions, Intravenous, pubmed-meshheading:10993761-Male, pubmed-meshheading:10993761-Myocardial Contraction, pubmed-meshheading:10993761-Norepinephrine, pubmed-meshheading:10993761-Peptides, pubmed-meshheading:10993761-Vasodilation, pubmed-meshheading:10993761-Vasodilator Agents, pubmed-meshheading:10993761-Ventricular Function, Left
pubmed:year
2000
pubmed:articleTitle
Effects of adrenomedullin on load and myocardial performance in normal and heart-failure dogs.
pubmed:affiliation
Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Physiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't