Source:http://linkedlifedata.com/resource/pubmed/id/10993761
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2000-10-12
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pubmed:abstractText |
Myocardial actions of the vasodilator peptide adrenomedullin (ADM) in the intact animal are unknown. Negative and positive inotropic actions have been reported in ex vivo experiments. Myocardial and load-altering actions of ADM in dogs before and after development of heart failure were studied. With controlled heart rate (atrial pacing) and after beta-blockade, ADM was administered to five normal dogs in doses of 20 ng. kg(-1). min(-1) iv, 100 ng. kg(-1). min(-1) iv, and 200 ng. kg(-1). min(-1) into the left ventricle (LV). LV peak systolic pressure and end-systolic volume decreased with each dose of ADM. End-systolic pressure decreased with the two higher doses. At the highest dose, arterial elastance and the time constant of LV isovolumic relaxation (tau) decreased, and LV end-systolic elastance (E(es)) increased. LV end-diastolic pressure and volume were unchanged. In five additional normal dogs receiving only the highest dose of ADM (200 ng. kg(-1). min(-1) intra-LV), to control for increased heart rate and sympathetic activation observed with the cumulative infusion, ADM produced arterial vasodilation but no change in E(es) or tau. In four dogs with pacing-induced heart failure, ADM (200 ng. kg(-1). min(-1) intra-LV) was without effect on tau, E(es), and systolic or diastolic pressure and volume. In vivo, ADM appears to be a selective arterial dilator without inotropic or lusitropic effects. The vasodilatory actions are attenuated in heart failure.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenomedullin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0363-6135
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
H1000-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10993761-Adrenomedullin,
pubmed-meshheading:10993761-Animals,
pubmed-meshheading:10993761-Blood Pressure,
pubmed-meshheading:10993761-Cardiac Pacing, Artificial,
pubmed-meshheading:10993761-Cyclic AMP,
pubmed-meshheading:10993761-Disease Models, Animal,
pubmed-meshheading:10993761-Dogs,
pubmed-meshheading:10993761-Dose-Response Relationship, Drug,
pubmed-meshheading:10993761-Epinephrine,
pubmed-meshheading:10993761-Heart,
pubmed-meshheading:10993761-Heart Failure,
pubmed-meshheading:10993761-Heart Rate,
pubmed-meshheading:10993761-Infusions, Intravenous,
pubmed-meshheading:10993761-Male,
pubmed-meshheading:10993761-Myocardial Contraction,
pubmed-meshheading:10993761-Norepinephrine,
pubmed-meshheading:10993761-Peptides,
pubmed-meshheading:10993761-Vasodilation,
pubmed-meshheading:10993761-Vasodilator Agents,
pubmed-meshheading:10993761-Ventricular Function, Left
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pubmed:year |
2000
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pubmed:articleTitle |
Effects of adrenomedullin on load and myocardial performance in normal and heart-failure dogs.
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pubmed:affiliation |
Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Physiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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