Linked Life Data

10993629

Source:http://linkedlifedata.com/resource/pubmed/id/10993629

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2000-9-28
pubmed:abstractText
PURPOSE: To discuss the effects of chromosome structure on the inter- and intrachromosomal exchanges in the framework of the model, which argues that the higher-order chromosome structure contains 10-30 Mbp loop clusters (micelles). RESULTS AND CONCLUSIONS: Intermicelle contacts determine exchange-type chromosome aberrations. Ratios of inter- to intrachromosomal exchanges calculated in the model are similar to the experimental data (literature) for human lymphocytes and flat fibroblasts. The frequency of interchanges is affected by nuclear shape; this might explain the greater number of interchanges observed in 3-D spherical lymphocytes vs. that in 2-D flat fibroblasts. Chromosome configuration (linear vs. folded Rab1) affects the pattern of micelle contacts. The model predicts that chromosomes in haploid Tradescantia microspores have the folded Rab1 orientation; this explains quantitatively the low value of the ratio of dicentrics to centric rings observed in these cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0955-3002
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1179-87
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Higher-order structure of interphase chromosomes and radiation-induced chromosomal exchange aberrations.
pubmed:affiliation
Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA. ostasj23@hscbklyn.edu
pubmed:publicationType
Journal Article