Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-10-5
pubmed:abstractText
The daily rhythm in circulating melatonin is driven by a circadian rhythm in the expression of the arylalkylamine N:-acetyltransferase gene in the rat pineal gland. Turning off expression of this gene at the end of night is believed to involve inhibitory transcription factors, among which Fos-related antigen 2 (Fra-2) appears as a good candidate. Circadian rhythms in the expression of three proteins of activating protein-1 (AP-1) complexes, namely, Fra-2, c-Jun, and Jun-D, are shown here to account for circadian variations in AP-1 binding activity. Quantitative variations in the Fra-2 component over the circadian cycle were associated with qualitative variations in protein isoforms. Destruction of the suprachiasmatic nucleus resulted in decreased nocturnal AP-1 activity, showing that AP-1 circadian rhythm is driven by this nucleus. Exposure to light during subjective night and administration of a serotonin 5-HT(1A)/5-HT(7) receptor agonist during subjective day, respectively, induced a 50% decrease and a 50% increase in both AP-1 and Fra-2 expression. These effects were impaired by suprachiasmatic nucleus lesions. These data show that pineal AP-1 binding activity, which results from Fra-2 expression, can be modulated by light and serotonin through the suprachiasmatic nucleus according to a "phase dependence" that is characteristic of the rhythm of clock sensitivity to both zeitgebers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Arylamine N-Acetyltransferase, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Fos-Related Antigen-2, http://linkedlifedata.com/resource/pubmed/chemical/Fosl2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Melatonin, http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3042
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1398-407
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:10987819-Analysis of Variance, pubmed-meshheading:10987819-Animals, pubmed-meshheading:10987819-Arylamine N-Acetyltransferase, pubmed-meshheading:10987819-Biological Clocks, pubmed-meshheading:10987819-Circadian Rhythm, pubmed-meshheading:10987819-DNA-Binding Proteins, pubmed-meshheading:10987819-Darkness, pubmed-meshheading:10987819-Fos-Related Antigen-2, pubmed-meshheading:10987819-Light, pubmed-meshheading:10987819-Male, pubmed-meshheading:10987819-Melatonin, pubmed-meshheading:10987819-Pineal Gland, pubmed-meshheading:10987819-Protein Isoforms, pubmed-meshheading:10987819-Proto-Oncogene Proteins c-fos, pubmed-meshheading:10987819-Proto-Oncogene Proteins c-jun, pubmed-meshheading:10987819-Rats, pubmed-meshheading:10987819-Rats, Sprague-Dawley, pubmed-meshheading:10987819-Serotonin, pubmed-meshheading:10987819-Suprachiasmatic Nucleus, pubmed-meshheading:10987819-Transcription Factor AP-1, pubmed-meshheading:10987819-Transcription Factors
pubmed:year
2000
pubmed:articleTitle
Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers.
pubmed:affiliation
INSERM U501, Institut Fédératif Jean-Roche, Faculté de Médecine Nord, Université de la Méditerranée, Marseille, France.
pubmed:publicationType
Journal Article