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pubmed-article:10987429pubmed:abstractTextA series of thiazole benzenesulfonamide-substituted 3-pyridylethanolamines was prepared and evaluated for their human beta3 adrenergic receptor agonist activity. Incorporation of aryl and heteroaryl substitution in the 4-position of the thiazole ring resulted in a number of highly potent and selective beta3 agonists. Results of preliminary in vivo evaluation of several of these compounds is described.lld:pubmed
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pubmed-article:10987429pubmed:articleTitlePotent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore.lld:pubmed
pubmed-article:10987429pubmed:affiliationDepartment of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. robert_mathvink@merck.comlld:pubmed
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