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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2001-1-4
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pubmed:abstractText |
A series of thiazole benzenesulfonamide-substituted 3-pyridylethanolamines was prepared and evaluated for their human beta3 adrenergic receptor agonist activity. Incorporation of aryl and heteroaryl substitution in the 4-position of the thiazole ring resulted in a number of highly potent and selective beta3 agonists. Results of preliminary in vivo evaluation of several of these compounds is described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:CandeloreM RMR,
pubmed-author:CascieriM AMA,
pubmed-author:ChittyDD,
pubmed-author:ColwellL FLFJr,
pubmed-author:DenkHH,
pubmed-author:FeeneyW PWP,
pubmed-author:FisherM HMH,
pubmed-author:ForrestM JMJ,
pubmed-author:IRAG HGH,
pubmed-author:MacIntyreD EDE,
pubmed-author:MathvinkR JRJ,
pubmed-author:TolmanJ SJS,
pubmed-author:TothKK,
pubmed-author:WeberA EAE,
pubmed-author:WyvrattM JMJ
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1971-3
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
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pubmed:year |
2000
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pubmed:articleTitle |
Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. robert_mathvink@merck.com
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pubmed:publicationType |
Journal Article
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