Source:http://linkedlifedata.com/resource/pubmed/id/10987424
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
17
|
| pubmed:dateCreated |
2001-1-4
|
| pubmed:abstractText |
The cyclic peptide ANP 4-23 and the linear peptide analogue AP-811 have been shown to be selective ANP-CR antagonists. Via alanine scanning and truncation studies we sought to determine which residues in these molecules were important in their binding to the clearance receptor and the relationship between these two molecules. These studies show that several modifications to these compounds are possible which improve physical properties of these molecules while retaining high affinity for the ANP-CR.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0960-894X
|
| pubmed:author |
pubmed-author:AharonyDD,
pubmed-author:AlfordV CVC,
pubmed-author:BanvilleD LDL,
pubmed-author:BialeckiR ARA,
pubmed-author:BrownF JFJ,
pubmed-author:DamewoodJ RJRJr,
pubmed-author:DantzmanC LCL,
pubmed-author:EdwardsP DPD,
pubmed-author:Garcia-DavenportL ELE,
pubmed-author:JacobsR TRT,
pubmed-author:MaugerR CRC,
pubmed-author:MurphyM MMM,
pubmed-author:PalmerWW,
pubmed-author:PattP GPG,
pubmed-author:RumseyW LWL,
pubmed-author:ShawAA,
pubmed-author:SteelmanG BGB,
pubmed-author:SurianJ MJM,
pubmed-author:VacekE PEP,
pubmed-author:VealeC ACA
|
| pubmed:issnType |
Print
|
| pubmed:day |
4
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1949-52
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| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
2000
|
| pubmed:articleTitle |
The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1.
|
| pubmed:affiliation |
Department of Chemistry, AstraZeneca Pharmaceuticals, Wilmington, DE 19850-5437, USA. chris.veale@astrazeneca.com
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| pubmed:publicationType |
Journal Article
|