Linked Life Data

10986584

Source:http://linkedlifedata.com/resource/pubmed/id/10986584

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-2-2
pubmed:abstractText
Modeling methods have been employed to further characterize the physical and physiologic processes of filling and diastolic function. They have led to more detailed understanding of the effect of alteration of physiologic parameters on the Doppler E-wave contour as well as pulmonary vein flow. Depending on the modeling approach, different aspects of the filling process have been considered from AV gradient and net compliance to atrial appendage function to the mechanical suction pump attribute of the heart. The models have been applied for further characterization of diastolic function and elucidation of novel basic physiologic relations. We trust that readers recognize that this article could not serve as a comprehensive and global review of the state-of-the-art in physiologic modeling, but rather as a selective overview, with emphasis on the main modeling principles and options currently in use. Modeling of systems physiology, especially as it relates to the function of the four-chamber heart, remains a fertile area of investigation. Future progress is likely to have profound influence on (noninvasive) diagnosis and quantitation of the effect of therapy and lead to continued discovery of "new" (macroscopic, cellular, and molecular biologic) physiology.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0733-8651
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
459-87
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Modeling of diastole.
pubmed:affiliation
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA. sjk@howdy.wustl.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't