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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-10-12
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pubmed:abstractText |
The aim of the present study was to analyse the correlation between functional and electrophysiological effects of the opioids in guinea pig ileum. Preparations of guinea pig ileum myenteric plexus-longitudinal muscle strips were used to compare the effect of two opioids, morphine (a mu-agonist) and U-50,488H (a kappa-agonist) on the electrically-induced contractile response and the excitatory postsynaptic potentials exhibited by the myenteric neurones when the internodal strands are electrically stimulated. Both opioids dose-dependently inhibited the contractile responses and the fast excitatory postsynaptic potentials (fEPSPs) in S neurones but did not modify the amplitude of the slow postsynaptic potentials. Pertussis toxin pretreatment was able to antagonise the effects of both morphine and U-50,448H. From our results it can be suggested that the effect of the opioids on guinea pig ileum involves the inhibition of neuronal fEPSPs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dichloro-N-methyl-N-(2-(1-pyrrol...,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors, Bordetella
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
291
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10984624-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-ben...,
pubmed-meshheading:10984624-Animals,
pubmed-meshheading:10984624-Dose-Response Relationship, Drug,
pubmed-meshheading:10984624-Electric Stimulation,
pubmed-meshheading:10984624-Electrophysiology,
pubmed-meshheading:10984624-Excitatory Postsynaptic Potentials,
pubmed-meshheading:10984624-Guinea Pigs,
pubmed-meshheading:10984624-Ileum,
pubmed-meshheading:10984624-Morphine,
pubmed-meshheading:10984624-Muscle Contraction,
pubmed-meshheading:10984624-Myenteric Plexus,
pubmed-meshheading:10984624-Narcotic Antagonists,
pubmed-meshheading:10984624-Neurons,
pubmed-meshheading:10984624-Pertussis Toxin,
pubmed-meshheading:10984624-Receptors, Opioid, kappa,
pubmed-meshheading:10984624-Receptors, Opioid, mu,
pubmed-meshheading:10984624-Virulence Factors, Bordetella
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pubmed:year |
2000
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pubmed:articleTitle |
Blockade by pertussis toxin of the opioid effect on guinea pig ileum. Contractility and electrophysiological neuronal recording.
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pubmed:affiliation |
Departmento Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, 28040, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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