Linked Life Data

10984298

Source:http://linkedlifedata.com/resource/pubmed/id/10984298

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-10-20
pubmed:abstractText
Growth hormone (GH) deficiency in adults in associated with reduced muscular strength and peak oxygen uptake (peak Vo2). How these variables are influenced by long-term somatropin therapy in adults with childhood onset GH-deficiency has not been precisely defined. The effect of somatropin treatment in 20 childhood onset GH-deficient adults on muscular strength, maximal exercise capacity, and hormonal response to exercise were therefore examined in a double-blind placebo-controlled study with recombinant human GH (rhGH, 12 microg/kg/day) for 6 months, followed by 36 months of open-labeled uninterrupted therapy, after which treatment was stopped for 9 months. After 6 months of treatment, exercise capacity increased significantly, as assessed by time to exhaustion [mean change (95% CI) 0.8 (0.2, 1.4) min, P<0.05], total (accumulated) work [11.6 (0.8, 22.4) kJ, P<0.05] and peak Vo2 [2.6 (0.3, 4.9) ml/kg/min, P<0.01], whereas no significant changes were observed during placebo. This effect on exercise capacity remained unchanged during long-term somatropin treatment, mainly due to increased capacity among patients with isolated GH deficiency. Nine months after stopping treatment, peak Vo2 decreased by 11% from 32.8+/-2.5 to 29.1+/-2.1 ml/kg/min (P<0.05). Maximal muscular handgrip strength was not affected by treatment. Long-term GH therapy resulted in decreased respiratory exchange value (R value) at rest and during exercise (P<0.001), suggesting a metabolic role with increased fat combustion. Resting and submaximal noradrenaline levels decreased during somatropin treatment (P<0.05), while no effect was observed for other exercise-induced hormonal responses, including adrenaline, insulin, prolactin, renin, and ACTH. We conclude that somatropin therapy to childhood onset GH deficient adults has a favourable effect on exercise capacity and may have a potentially beneficial effect on plasma catecholamines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1096-6374
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
377-84
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:10984298-Adolescent, pubmed-meshheading:10984298-Adrenocorticotropic Hormone, pubmed-meshheading:10984298-Adult, pubmed-meshheading:10984298-Catecholamines, pubmed-meshheading:10984298-Exercise, pubmed-meshheading:10984298-Female, pubmed-meshheading:10984298-Follow-Up Studies, pubmed-meshheading:10984298-Growth Disorders, pubmed-meshheading:10984298-Hemodynamics, pubmed-meshheading:10984298-Hormones, pubmed-meshheading:10984298-Human Growth Hormone, pubmed-meshheading:10984298-Humans, pubmed-meshheading:10984298-Insulin, pubmed-meshheading:10984298-Lactates, pubmed-meshheading:10984298-Male, pubmed-meshheading:10984298-Middle Aged, pubmed-meshheading:10984298-Muscle, Skeletal, pubmed-meshheading:10984298-Oxygen, pubmed-meshheading:10984298-Prolactin, pubmed-meshheading:10984298-Pulmonary Gas Exchange
pubmed:year
1998
pubmed:articleTitle
Exercise capacity and hormonal response in adults with childhood onset growth hormone deficiency during long-term somatropin treatment.
pubmed:affiliation
Medical Department B, Rikshospitalet University Hospital, Oslo, Norway. lagulles@onlin.no
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Multicenter Study