Source:http://linkedlifedata.com/resource/pubmed/id/10984195
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2000-12-21
|
| pubmed:abstractText |
Cytokines in the central nervous system (CNS) may play an important role in functioning as intercellular signals that orchestrate the response to injury. Whether this is a cause or result of the brain disease process is uncertain. We investigated IFN-gamma, IL-2, IL-4, IL-6, and IgE in the sera of 38 patients with cerebral infarction during the acute stage and 10 normal controls using an originally devised sensitive sandwich enzyme-linked immunosorbent assay (ELISA). We found that serum levels of IL-2 derived from T helper 1 (Th1) cells were slightly reduced in patients with cerebral infarction, whereas serum levels of IL-4 and IL-6 derived from Th2 cells were elevated significantly. IL-4 induces synthesis of IgE in human B cells. Endogenous IL-6 plays an obligatory role in IL-4-dependent human IgE synthesis. We observed that serum IgE levels were elevated significantly in patients with cerebral infarction. However, serum IFN-gamma levels were not elevated significantly in cerebral infarction patients. These findings suggest that elevated IL-4, IL-6, and IgE levels in the human serum may be an important factor in cerebral infarction during the acute stage. Decrease of IL-2 levels in the serum of patients with cerebral infarction may be a regulatory mechanism.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0895-8696
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| pubmed:author |
pubmed-author:BaekS HSH,
pubmed-author:ChoK HKH,
pubmed-author:ColeT BTBJr,
pubmed-author:HanJJ,
pubmed-author:JeongH JHJ,
pubmed-author:KimK YKY,
pubmed-author:KimN SNS,
pubmed-author:LalK BKB,
pubmed-author:LamK BKB,
pubmed-author:LeeY MYM,
pubmed-author:MoonB SBS,
pubmed-author:ShinH YHY,
pubmed-author:SongH JHJ
|
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
191-6
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:10984195-Acute Disease,
pubmed-meshheading:10984195-Adult,
pubmed-meshheading:10984195-Aged,
pubmed-meshheading:10984195-Aged, 80 and over,
pubmed-meshheading:10984195-Cerebral Infarction,
pubmed-meshheading:10984195-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10984195-Female,
pubmed-meshheading:10984195-Humans,
pubmed-meshheading:10984195-Immunoglobulin E,
pubmed-meshheading:10984195-Interferon-gamma,
pubmed-meshheading:10984195-Interleukin-2,
pubmed-meshheading:10984195-Interleukin-4,
pubmed-meshheading:10984195-Interleukin-6,
pubmed-meshheading:10984195-Interleukins,
pubmed-meshheading:10984195-Male,
pubmed-meshheading:10984195-Middle Aged,
pubmed-meshheading:10984195-Th1 Cells,
pubmed-meshheading:10984195-Th2 Cells
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage.
|
| pubmed:affiliation |
Department of Oriental Pharmacy, College of Pharmacy, Center of Oriental Medicinal Science, Wonkwang University, Iksan-city, Chonbuk, South Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|