Linked Life Data

10983868

Source:http://linkedlifedata.com/resource/pubmed/id/10983868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-9-19
pubmed:abstractText
The present studies investigated the effects of L-deprenyl, 1-methyl-4-phenylpyridinium ion (MPP+) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the efflux of dopamine and its metabolites in microdialysates of striatum and nucleus accumbens in rats. L-Deprenyl or L-amphetamine perfusion into striatum had no effects on basal dopamine efflux, though L-deprenyl reduced the basal efflux of dihydroxyphenylacetic acid and homovanillic acid. MPP+ or MPTP perfusion into striatum significantly increased the dopamine efflux, and the action of MPTP was more potent than that of MPP+. Pretreatment with L-deprenyl antagonized the actions of MPP+ and MPTP. The striatal dopamine efflux of rats was gradually restored by itself after the overflow caused by 2-h perfusion of the dopaminergic neurotoxins, while L-deprenyl could not accelerate the recovery. Perfusion with L-deprenyl or L-amphetamine, but not pargyline, into nucleus accumbens increased the dopamine efflux in a dose-dependent fashion, which could be antagonized by haloperidol pretreatment. MPP+ or MPTP perfusion into nucleus accumbens also increased the dopamine efflux, and the action of MPTP was also more potent than that of MPP+. Pretreatment with L-deprenyl could not antagonize the actions of MPP+ and MPTP. These findings suggest that L-deprenyl, MPP+ and MPTP induce differential effects on nigrostriatal and mesolimbic dopaminergic pathways in vivo. L-Deprenyl has neuroprotective rather than neurorestorative action against MPP+- and MPTP-induced dopamine overflow from striatum. Further, L-deprenyl-induced dopamine overflow from nucleus accumbens may explain the amphetamine-like reinforcing property of L-deprenyl.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-50
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed-meshheading:10983868-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, pubmed-meshheading:10983868-1-Methyl-4-phenylpyridinium, pubmed-meshheading:10983868-Animals, pubmed-meshheading:10983868-Antiparkinson Agents, pubmed-meshheading:10983868-Chromatography, High Pressure Liquid, pubmed-meshheading:10983868-Corpus Striatum, pubmed-meshheading:10983868-Dopamine, pubmed-meshheading:10983868-Dopamine Agents, pubmed-meshheading:10983868-Dose-Response Relationship, Drug, pubmed-meshheading:10983868-Drug Interactions, pubmed-meshheading:10983868-Electrochemistry, pubmed-meshheading:10983868-Male, pubmed-meshheading:10983868-Microdialysis, pubmed-meshheading:10983868-Nucleus Accumbens, pubmed-meshheading:10983868-Rats, pubmed-meshheading:10983868-Rats, Sprague-Dawley, pubmed-meshheading:10983868-Selegiline
pubmed:year
2000
pubmed:articleTitle
Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens.
pubmed:affiliation
Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences. wrwu@vetmed.wsu.edu
pubmed:publicationType
Journal Article