Linked Life Data

10983406

Source:http://linkedlifedata.com/resource/pubmed/id/10983406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-11-15
pubmed:abstractText
Ribosome inactivating proteins (RIPs) are a group of naturally occurring plant proteins with a RNA-N-glycosidases activity which depurinate rRNA at a specific universally conserved position (i.e. cleavage of N-glycosidic bond of a specific adenine of 28S rRNA). These proteins are found in different parts of plants, in concentrations ranging from a few micrograms to several hundred mg per 100 g of plant tissues. RIPs exist in two forms, type 1 having a single polypeptide chain with a molecular mass of approximately 30 kDa possessing N-glycosidase activity; and type 2 with two or four polypeptide chains having a molecular mass of approximately 60 kDa and approximately 120 kDa respectively showing lectin activity along with N-glycosidase moiety. Such biomolecules causing cytotoxicity are being exploited for designing immunotoxins/hormonotoxins using heterobifunctional conjugates. These carrier conjugates with the RIPs can influence cellular trafficking and inhibition of protein synthesis. We are witnessing a novel protein from plants that can be utilised for various therapeutical treatments ranging from cancers, AIDS and other viral diseases of present times.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0301-1208
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-5
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Current status of ribosome inactivating proteins.
pubmed:affiliation
Hormone Biochemistry Laboratory, North-Eastern Hill University, Meghalaya, India.
pubmed:publicationType
Journal Article, Review