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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1975-11-5
|
| pubmed:abstractText |
The degree of new bone formation in isografts and allografts has been assessed by a radiotracer technique. Allografts used have been either H-1-identical or H-1-disparate with the recipient. It was found that new bone formation is curtailed within the first 3 weeks after grafting. This curtailment was significantly greater in those donor-recipient combinations which were H-1-identical but disparate for many weak locus antigens than those in which H-1 disparity existed with only a few minor locus differences. There was no late phase (i.e., host-derived) osteogenesis in the combination with H-1 identity, but multiple minor antigen disparities. In isografts and H-1-disparate grafts significant late phase osteogenesis was found in about 30% of recipients. Resorption of the graft was found to be significantly impaired in both H-1-identical and disparate grafts in comparison with isografts. There was a significant negative correlation between weight of the graft and degree of osteogenesis in isografts during the first 2 weeks after grafting, and also during the later phase (6-8 weeks). A similar negative correlation was found during the late phase in H-1-disparate grafts with few minor antigen disparities, but no correlation was found at any time in H-1-identical grafts with multiple minor antigen disparities.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0041-1337
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
416-23
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1098244-Animals,
pubmed-meshheading:1098244-Antigen-Antibody Reactions,
pubmed-meshheading:1098244-Bone Transplantation,
pubmed-meshheading:1098244-Bone and Bones,
pubmed-meshheading:1098244-Choristoma,
pubmed-meshheading:1098244-Histocompatibility Antigens,
pubmed-meshheading:1098244-Ilium,
pubmed-meshheading:1098244-Immunogenetics,
pubmed-meshheading:1098244-Male,
pubmed-meshheading:1098244-Osteoblasts,
pubmed-meshheading:1098244-Osteocytes,
pubmed-meshheading:1098244-Osteogenesis,
pubmed-meshheading:1098244-Rats,
pubmed-meshheading:1098244-Rats, Inbred Strains,
pubmed-meshheading:1098244-Strontium Radioisotopes,
pubmed-meshheading:1098244-Time Factors,
pubmed-meshheading:1098244-Tissue Survival,
pubmed-meshheading:1098244-Transplantation, Homologous,
pubmed-meshheading:1098244-Transplantation, Isogeneic
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
Studies of the behaviour of allogeneic cancellous bone grafts in inbred rats.
|
| pubmed:publicationType |
Journal Article
|