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rdf:type |
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lifeskim:mentions |
umls-concept:C0011854,
umls-concept:C0220825,
umls-concept:C0392760,
umls-concept:C0796366,
umls-concept:C0936012,
umls-concept:C1332838,
umls-concept:C1333530,
umls-concept:C1414945,
umls-concept:C1415869,
umls-concept:C1708726,
umls-concept:C1838261
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pubmed:issue |
1
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pubmed:dateCreated |
2000-9-22
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pubmed:abstractText |
Previous studies have identified a susceptibility region for insulin-dependent (type 1) diabetes mellitus on chromosome 11q13 (IDDM4). In this study, 15 polymorphic markers were analyzed for 382 affected sibpair (ASP) families with type 1 diabetes. Our analyses provided additional evidence for linkage for IDDM4 (a peak LOD score of 3.4 at D11S913). The markers with strong linkage evidence are located within an interval of approximately 6 cM between D11S4205 and GALN. We also identified polymorphisms in two candidate genes, Fas-associated death domain protein (FADD) and galanin (GALN). Analyses of the data by transmission/disequilibrium test (TDT) and extended TDT (ETDT) did not provide any evidence for association/linkage with these candidate genes. However, ETDT did reveal significant association/linkage with the marker D11S987 (P=0.0004) within the IDDM4 interval defined by ASP analyses, suggesting that IDDM4 may be in the close proximity of D11S987.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0340-6717
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10982176-Bacterial Proteins,
pubmed-meshheading:10982176-Chromosome Mapping,
pubmed-meshheading:10982176-Chromosomes, Human, Pair 11,
pubmed-meshheading:10982176-Coenzyme A Ligases,
pubmed-meshheading:10982176-DNA Mutational Analysis,
pubmed-meshheading:10982176-Diabetes Mellitus, Type 1,
pubmed-meshheading:10982176-Escherichia coli Proteins,
pubmed-meshheading:10982176-Family Health,
pubmed-meshheading:10982176-Galanin,
pubmed-meshheading:10982176-Genetic Markers,
pubmed-meshheading:10982176-Genetic Predisposition to Disease,
pubmed-meshheading:10982176-Genotype,
pubmed-meshheading:10982176-Humans,
pubmed-meshheading:10982176-Linkage Disequilibrium,
pubmed-meshheading:10982176-Microsatellite Repeats,
pubmed-meshheading:10982176-Polymorphism, Genetic,
pubmed-meshheading:10982176-Polymorphism, Single-Stranded Conformational
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pubmed:year |
2000
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pubmed:articleTitle |
Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses.
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pubmed:affiliation |
Department of Pathology, Immunology and Laboratory Medicine, and Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville 32610, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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