| pubmed-article:1098088 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1098088 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1098088 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1098088 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:1098088 | lifeskim:mentions | umls-concept:C0002600 | lld:lifeskim |
| pubmed-article:1098088 | lifeskim:mentions | umls-concept:C0011685 | lld:lifeskim |
| pubmed-article:1098088 | lifeskim:mentions | umls-concept:C0020934 | lld:lifeskim |
| pubmed-article:1098088 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1098088 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:1098088 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:1098088 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1098088 | pubmed:dateCreated | 1975-11-6 | lld:pubmed |
| pubmed-article:1098088 | pubmed:abstractText | 3H-L-Dopa was given to rats after a peripheral decarboxylase inhibitor Ro 4-4602 (50 mg/kg) and the effect of 30 min pretreatment with antiptyline (10 mg/kg), desipramine (10 mg/kg) and imipramine (10 mg/kg) on the brain formation of 3H-dopamine, 3H-noradrenaline and their major metabolites was investigated. Desipramine produced a decrease in the level of labelled noradrenaline and its major metabolites free and conjugated 3-methoxy-4-hydroxyphenyleneglycol and 3,4-dihydroxyphenyleneglycol. Imipramine decreased labelled noradrenaline and 3-methoxy-4-hydroxyphenyleneglycol, whereas amitriptyline produced no significant effect on noradrenaline metabolism. The thymoleptic drugs produced no significant effect on endogenous brain noradrenaline and dopamine. These findings provide a strong indication that desipramine and imipramine inhibit the 3H-noradrenaline biosynthesis from 3H-L-Dopamthe effect seems closely related to the well-known membrane inhibitory effect of these drugs, since desipramine produced a more marked effect than imipramine and amitriptyline showed no effect. No conclusive evidence for the precise mechanism of action was obtained but it is possible that the decreased 3H-noradrenaline synthesis is related to interference of desipramine and imipramine with the precursor (s) 3H-L-Dopa or 3H-dopamine at sites of 3H-noradrenaline biosynthesis. | lld:pubmed |
| pubmed-article:1098088 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1098088 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1098088 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1098088 | pubmed:issn | 0033-3158 | lld:pubmed |
| pubmed-article:1098088 | pubmed:author | pubmed-author:Scheel-Krüger... | lld:pubmed |
| pubmed-article:1098088 | pubmed:author | pubmed-author:NielsenMM | lld:pubmed |
| pubmed-article:1098088 | pubmed:author | pubmed-author:EplovLL | lld:pubmed |
| pubmed-article:1098088 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1098088 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:1098088 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1098088 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1098088 | pubmed:pagination | 249-54 | lld:pubmed |
| pubmed-article:1098088 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:1098088 | pubmed:meshHeading | pubmed-meshheading:1098088-... | lld:pubmed |
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| pubmed-article:1098088 | pubmed:meshHeading | pubmed-meshheading:1098088-... | lld:pubmed |
| pubmed-article:1098088 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1098088 | pubmed:articleTitle | The effect of amitriptyline, desipramine and imipramine on the vivo brain synthesis of 3H-noradrenaline from 3H-L-dopa in the rat. | lld:pubmed |
| pubmed-article:1098088 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1098088 | lld:pubmed |
