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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1975-11-6
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pubmed:abstractText |
3H-L-Dopa was given to rats after a peripheral decarboxylase inhibitor Ro 4-4602 (50 mg/kg) and the effect of 30 min pretreatment with antiptyline (10 mg/kg), desipramine (10 mg/kg) and imipramine (10 mg/kg) on the brain formation of 3H-dopamine, 3H-noradrenaline and their major metabolites was investigated. Desipramine produced a decrease in the level of labelled noradrenaline and its major metabolites free and conjugated 3-methoxy-4-hydroxyphenyleneglycol and 3,4-dihydroxyphenyleneglycol. Imipramine decreased labelled noradrenaline and 3-methoxy-4-hydroxyphenyleneglycol, whereas amitriptyline produced no significant effect on noradrenaline metabolism. The thymoleptic drugs produced no significant effect on endogenous brain noradrenaline and dopamine. These findings provide a strong indication that desipramine and imipramine inhibit the 3H-noradrenaline biosynthesis from 3H-L-Dopamthe effect seems closely related to the well-known membrane inhibitory effect of these drugs, since desipramine produced a more marked effect than imipramine and amitriptyline showed no effect. No conclusive evidence for the precise mechanism of action was obtained but it is possible that the decreased 3H-noradrenaline synthesis is related to interference of desipramine and imipramine with the precursor (s) 3H-L-Dopa or 3H-dopamine at sites of 3H-noradrenaline biosynthesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dihydroxyphenylacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/3-Methoxy-4-hydroxyphenylethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Amitriptyline,
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents, Tricyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Benserazide,
http://linkedlifedata.com/resource/pubmed/chemical/Desipramine,
http://linkedlifedata.com/resource/pubmed/chemical/Imipramine,
http://linkedlifedata.com/resource/pubmed/chemical/Levodopa,
http://linkedlifedata.com/resource/pubmed/chemical/Methoxyhydroxyphenylglycol,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Normetanephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptamines
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pubmed:status |
MEDLINE
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
249-54
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1098088-3,4-Dihydroxyphenylacetic Acid,
pubmed-meshheading:1098088-3-Methoxy-4-hydroxyphenylethanol,
pubmed-meshheading:1098088-Amitriptyline,
pubmed-meshheading:1098088-Animals,
pubmed-meshheading:1098088-Antidepressive Agents, Tricyclic,
pubmed-meshheading:1098088-Benserazide,
pubmed-meshheading:1098088-Brain,
pubmed-meshheading:1098088-Chromatography, Thin Layer,
pubmed-meshheading:1098088-Desipramine,
pubmed-meshheading:1098088-Dopamine,
pubmed-meshheading:1098088-Imipramine,
pubmed-meshheading:1098088-Levodopa,
pubmed-meshheading:1098088-Male,
pubmed-meshheading:1098088-Methoxyhydroxyphenylglycol,
pubmed-meshheading:1098088-Norepinephrine,
pubmed-meshheading:1098088-Normetanephrine,
pubmed-meshheading:1098088-Rats,
pubmed-meshheading:1098088-Tryptamines
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pubmed:year |
1975
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pubmed:articleTitle |
The effect of amitriptyline, desipramine and imipramine on the vivo brain synthesis of 3H-noradrenaline from 3H-L-dopa in the rat.
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pubmed:publicationType |
Journal Article
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